Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist?
ABSTRACT Objective The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist. Subjects and methods Pa...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2017-02-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000300276&lng=en&tlng=en |
| _version_ | 1818108231242743808 |
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| author | Rodrigo Bremer Nones Cláudia Pontes Ivantes Maria Lucia Alves Pedroso |
| author_facet | Rodrigo Bremer Nones Cláudia Pontes Ivantes Maria Lucia Alves Pedroso |
| author_sort | Rodrigo Bremer Nones |
| collection | DOAJ |
| description | ABSTRACT Objective The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist. Subjects and methods Patients referred by endocrinologists to the liver outpatient departments in two hospitals in Curitiba, Brazil, over a 72-month period were analyzed. The results calculated using the APRI, FIB 4, FORNS and NAFLD Fibrosis Score non-invasive liver fibrosis assessment models were analyzed and compared with histological staging of this population. Results Sixty-seven patients with NAFLD were analyzed. Forty-two of them (62.68%) were female, mean age was 54.76 (±9.63) years, mean body mass index 31.42 (±5.64) and 59 (88.05%) of the 67 cases had glucose intolerance or diabetes. A diagnosis of steatohepatitis was made in 45 (76.27%) of the 59 biopsied patients, and advanced liver fibrosis (stages 3 and 4) was diagnosed in 18 (26.86%) of the 67 patients in the study population. The FIB 4 and NAFLD Fibrosis Score models had a high negative predictive value (93.48% and 93.61%, respectively) in patients with severe liver fibrosis (stages 3 and 4). Conclusion In conclusion, use of the FIB 4 and NAFLD Fibrosis Score models in NAFLD patients allows a diagnosis of severe liver disease to be excluded. |
| first_indexed | 2024-12-11T02:12:04Z |
| format | Article |
| id | doaj.art-5a5bff9fdf9e4bd1991e4d012657c1b2 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-11T02:12:04Z |
| publishDate | 2017-02-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-5a5bff9fdf9e4bd1991e4d012657c1b22022-12-22T01:24:16ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922017-02-0161327628110.1590/2359-3997000000233S2359-39972017000300276Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist?Rodrigo Bremer NonesCláudia Pontes IvantesMaria Lucia Alves PedrosoABSTRACT Objective The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist. Subjects and methods Patients referred by endocrinologists to the liver outpatient departments in two hospitals in Curitiba, Brazil, over a 72-month period were analyzed. The results calculated using the APRI, FIB 4, FORNS and NAFLD Fibrosis Score non-invasive liver fibrosis assessment models were analyzed and compared with histological staging of this population. Results Sixty-seven patients with NAFLD were analyzed. Forty-two of them (62.68%) were female, mean age was 54.76 (±9.63) years, mean body mass index 31.42 (±5.64) and 59 (88.05%) of the 67 cases had glucose intolerance or diabetes. A diagnosis of steatohepatitis was made in 45 (76.27%) of the 59 biopsied patients, and advanced liver fibrosis (stages 3 and 4) was diagnosed in 18 (26.86%) of the 67 patients in the study population. The FIB 4 and NAFLD Fibrosis Score models had a high negative predictive value (93.48% and 93.61%, respectively) in patients with severe liver fibrosis (stages 3 and 4). Conclusion In conclusion, use of the FIB 4 and NAFLD Fibrosis Score models in NAFLD patients allows a diagnosis of severe liver disease to be excluded.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000300276&lng=en&tlng=enNAFLDnonalcoholic steatohepatitismathematical modelliver fibrosisspecialist |
| spellingShingle | Rodrigo Bremer Nones Cláudia Pontes Ivantes Maria Lucia Alves Pedroso Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist? Archives of Endocrinology and Metabolism NAFLD nonalcoholic steatohepatitis mathematical model liver fibrosis specialist |
| title | Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist? |
| title_full | Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist? |
| title_fullStr | Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist? |
| title_full_unstemmed | Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist? |
| title_short | Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist? |
| title_sort | can fib4 and nafld fibrosis scores help endocrinologists refer patients with non alcoholic fat liver disease to a hepatologist |
| topic | NAFLD nonalcoholic steatohepatitis mathematical model liver fibrosis specialist |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000300276&lng=en&tlng=en |
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