Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs
Lung cancer is the second leading cause of cancer-related death worldwide. In recent decades, investigators have found that microRNAs, a group of non-coding RNAs, are abnormally expressed in lung cancer, and play important roles in the initiation and progression of lung cancer. These microRNAs have...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/18/5903 |
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| author | Jing Li Xianmei Zhong Yueshui Zhao Jing Shen Chalermchai Pilapong Zhangang Xiao |
| author_facet | Jing Li Xianmei Zhong Yueshui Zhao Jing Shen Chalermchai Pilapong Zhangang Xiao |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Lung cancer is the second leading cause of cancer-related death worldwide. In recent decades, investigators have found that microRNAs, a group of non-coding RNAs, are abnormally expressed in lung cancer, and play important roles in the initiation and progression of lung cancer. These microRNAs have been used as biomarkers and potential therapeutic targets of lung cancer. Polyphenols are natural and bioactive chemicals that are synthesized by plants, and have promising anticancer effects against several kinds of cancer, including lung cancer. Recent studies identified that polyphenols exert their anticancer effects by regulating the expression levels of microRNAs in lung cancer. Targeting microRNAs using polyphenols may provide a novel strategy for the prevention and treatment of lung cancer. In this review, we reviewed the effects of polyphenols on oncogenic and tumor-suppressive microRNAs in lung cancer. We also reviewed and discussed the potential clinical application of polyphenol-regulated microRNAs in lung cancer treatment. |
| first_indexed | 2024-03-09T23:01:56Z |
| format | Article |
| id | doaj.art-5a5c401996e2448ea578978e58f12aa6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:01:56Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5a5c401996e2448ea578978e58f12aa62023-11-23T18:00:54ZengMDPI AGMolecules1420-30492022-09-012718590310.3390/molecules27185903Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAsJing Li0Xianmei Zhong1Yueshui Zhao2Jing Shen3Chalermchai Pilapong4Zhangang Xiao5Department of Oncology and Hematology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, ChinaLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, ChinaLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, ChinaLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, ChinaCenter of Excellence for Molecular Imaging (CEMI), Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, ChinaLung cancer is the second leading cause of cancer-related death worldwide. In recent decades, investigators have found that microRNAs, a group of non-coding RNAs, are abnormally expressed in lung cancer, and play important roles in the initiation and progression of lung cancer. These microRNAs have been used as biomarkers and potential therapeutic targets of lung cancer. Polyphenols are natural and bioactive chemicals that are synthesized by plants, and have promising anticancer effects against several kinds of cancer, including lung cancer. Recent studies identified that polyphenols exert their anticancer effects by regulating the expression levels of microRNAs in lung cancer. Targeting microRNAs using polyphenols may provide a novel strategy for the prevention and treatment of lung cancer. In this review, we reviewed the effects of polyphenols on oncogenic and tumor-suppressive microRNAs in lung cancer. We also reviewed and discussed the potential clinical application of polyphenol-regulated microRNAs in lung cancer treatment.https://www.mdpi.com/1420-3049/27/18/5903polyphenollung cancermicroRNA |
| spellingShingle | Jing Li Xianmei Zhong Yueshui Zhao Jing Shen Chalermchai Pilapong Zhangang Xiao Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs Molecules polyphenol lung cancer microRNA |
| title | Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs |
| title_full | Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs |
| title_fullStr | Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs |
| title_full_unstemmed | Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs |
| title_short | Polyphenols as Lung Cancer Chemopreventive Agents by Targeting microRNAs |
| title_sort | polyphenols as lung cancer chemopreventive agents by targeting micrornas |
| topic | polyphenol lung cancer microRNA |
| url | https://www.mdpi.com/1420-3049/27/18/5903 |
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