Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model.

Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model.

To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal precursor cells exposed to glaucoma-relevant stress conditions.RGC5 cells transfected with expression constructs for MARCH5, MARCH5(H43W), Dpr1(...

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Bibliographic Details
Main Authors:	Lei Fang, Charles Hemion, David Goldblum, Peter Meyer, Selim Orgül, Stephan Frank, Josef Flammer, Albert Neutzner
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3526576?pdf=render

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