Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis
Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors. The recipe of Mongolian medicine Sendeng Decoction was recorded in “The Pleasure of the Viewer” compiled by Jigwood Danjinzhamusu. Mongolian medicine clinical experience proved that Sendeng Decocti...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Medicine in Novel Technology and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093522000418 |
| _version_ | 1828090269424156672 |
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| author | Li Sun Guanyu Yu Huiming Jiang Kun Shi Doudou Huang Hashen Bao Yanping Huang Limuge Che Meijuan Chen |
| author_facet | Li Sun Guanyu Yu Huiming Jiang Kun Shi Doudou Huang Hashen Bao Yanping Huang Limuge Che Meijuan Chen |
| author_sort | Li Sun |
| collection | DOAJ |
| description | Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors. The recipe of Mongolian medicine Sendeng Decoction was recorded in “The Pleasure of the Viewer” compiled by Jigwood Danjinzhamusu. Mongolian medicine clinical experience proved that Sendeng Decoction had good antipyretic, analgesic, anti-inflammatory and anti-rheumatism effect. However, the mechanism of this drug in psoriasis is still unclear. In this study, imiquimod cream (IMQ) was used to construct psoriasis model in 8-week-old male BALB/c mice, and Sendeng Decoction was used to treat the mice with psoriasis. The results showed that PASI score and spleen index decreased after Sendeng Decoction treatment. Meanwhile, HE staining showed that the pathological structure was improved, flow cytometry results showed that the proportion of Treg cells increased and Th17 cells decreased, and results of Western blot showed that the level of p38 MAPK, p-p38 MAPK, p-STAT3 and p-JAK1 decreased observably. More importantly, the above results were most significant in Sendeng's M group, which was similar to MTX group. Our results indicated that Mongolian medicine Sendeng Decoction can effectively relieve the symptoms of psoriasis mice induced by IMQ, mainly by regulating the ratio of Th17/Treg cells through the JAK/STAT and p38 MAPK pathways to reduce the inflammatory state in mice, thereby improving the symptoms of dermatitis. |
| first_indexed | 2024-04-11T05:54:14Z |
| format | Article |
| id | doaj.art-5a5d273383344719af92ecc842c7ab70 |
| institution | Directory Open Access Journal |
| issn | 2590-0935 |
| language | English |
| last_indexed | 2024-04-11T05:54:14Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Novel Technology and Devices |
| spelling | doaj.art-5a5d273383344719af92ecc842c7ab702022-12-22T04:41:57ZengElsevierMedicine in Novel Technology and Devices2590-09352022-12-0116100154Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasisLi Sun0Guanyu Yu1Huiming Jiang2Kun Shi3Doudou Huang4Hashen Bao5Yanping Huang6Limuge Che7Meijuan Chen8Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China; Corresponding author.Chifeng Hospital, Chifeng, 024099, ChinaNanjing University of Chinese Medicine, Nanjing, 210023, China; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, ChinaNanjing University of Chinese Medicine, Nanjing, 210023, ChinaNanjing University of Chinese Medicine, Nanjing, 210023, ChinaMongolia Medical College, Inner Mongolia Medical University, Hohhot, 010107, ChinaAffiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, ChinaMedical Innovation Center for Nationalities, Inner Mongolia Medical University, Hohhot, 010107, ChinaNanjing University of Chinese Medicine, Nanjing, 210023, China; Corresponding author.Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors. The recipe of Mongolian medicine Sendeng Decoction was recorded in “The Pleasure of the Viewer” compiled by Jigwood Danjinzhamusu. Mongolian medicine clinical experience proved that Sendeng Decoction had good antipyretic, analgesic, anti-inflammatory and anti-rheumatism effect. However, the mechanism of this drug in psoriasis is still unclear. In this study, imiquimod cream (IMQ) was used to construct psoriasis model in 8-week-old male BALB/c mice, and Sendeng Decoction was used to treat the mice with psoriasis. The results showed that PASI score and spleen index decreased after Sendeng Decoction treatment. Meanwhile, HE staining showed that the pathological structure was improved, flow cytometry results showed that the proportion of Treg cells increased and Th17 cells decreased, and results of Western blot showed that the level of p38 MAPK, p-p38 MAPK, p-STAT3 and p-JAK1 decreased observably. More importantly, the above results were most significant in Sendeng's M group, which was similar to MTX group. Our results indicated that Mongolian medicine Sendeng Decoction can effectively relieve the symptoms of psoriasis mice induced by IMQ, mainly by regulating the ratio of Th17/Treg cells through the JAK/STAT and p38 MAPK pathways to reduce the inflammatory state in mice, thereby improving the symptoms of dermatitis.http://www.sciencedirect.com/science/article/pii/S2590093522000418PsoriasisMongolian medicine sendeng decoctionTh17/treg cell balanceInflammatoryJAK/STATp38 MAPK |
| spellingShingle | Li Sun Guanyu Yu Huiming Jiang Kun Shi Doudou Huang Hashen Bao Yanping Huang Limuge Che Meijuan Chen Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis Medicine in Novel Technology and Devices Psoriasis Mongolian medicine sendeng decoction Th17/treg cell balance Inflammatory JAK/STAT p38 MAPK |
| title | Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis |
| title_full | Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis |
| title_fullStr | Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis |
| title_full_unstemmed | Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis |
| title_short | Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis |
| title_sort | experimental study on the anti inflammatory effect of mongolian medicine sendeng decoction on mice with psoriasis |
| topic | Psoriasis Mongolian medicine sendeng decoction Th17/treg cell balance Inflammatory JAK/STAT p38 MAPK |
| url | http://www.sciencedirect.com/science/article/pii/S2590093522000418 |
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