Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats
For localized tumors, gold nanorod (AuNR)-assisted plasmonic photothermal therapy (PPTT) is a potentially effective alternative to traditional surgery, in which AuNRs absorb near-infrared light and convert it to heat in order to kill cancer cells. However, for large tumors (volume ≥ 20 cm&...
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| Format: | Article |
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MDPI AG
2019-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/6/851 |
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| author | Moustafa R. K. Ali Haithem A. M. Farghali Yue Wu Ivan El-Sayed Ahmed H. Osman Salah A. Selim Mostafa A. El-Sayed |
| author_facet | Moustafa R. K. Ali Haithem A. M. Farghali Yue Wu Ivan El-Sayed Ahmed H. Osman Salah A. Selim Mostafa A. El-Sayed |
| author_sort | Moustafa R. K. Ali |
| collection | DOAJ |
| description | For localized tumors, gold nanorod (AuNR)-assisted plasmonic photothermal therapy (PPTT) is a potentially effective alternative to traditional surgery, in which AuNRs absorb near-infrared light and convert it to heat in order to kill cancer cells. However, for large tumors (volume ≥ 20 cm<sup>3</sup>), an uneven distribution of AuNRs might cause inhomogeneity of the heat distribution inside the tumor. Surgery is frequently recommended for removing large tumors, but it is associated with a high risk of cancer recurrence and metastasis. Here, we applied PPTT before surgery, which showed improved treatment for large tumors. We divided the animals (eight cats/dogs) into two groups: Group I (control), where three cases were solely treated with surgery, laser, or AuNRs alone, resulting in recurrence and metastasis; and Group II, where animals were treated with PPTT before surgery. In Group II, four out of the five cases had tumor regression without any recurrence or metastasis. Interestingly, we observed that applying PPTT before surgery displayed reduced bleeding during tumor removal, supported by histopathology that showed altered blood vessels. In conclusion, our study showed that applying AuNR-assisted PPTT (AuNRs-PPTT) before surgery could significantly affect blood vessels inside the tumor, leading to a decreased amount of bleeding during surgery, which can potentially decrease the risk of metastasis and blood loss during surgery. |
| first_indexed | 2024-03-12T10:39:34Z |
| format | Article |
| id | doaj.art-5a5e1f71ff254457917451b23a55962c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:39:34Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5a5e1f71ff254457917451b23a55962c2023-09-02T08:18:18ZengMDPI AGCancers2072-66942019-06-0111685110.3390/cancers11060851cancers11060851Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and CatsMoustafa R. K. Ali0Haithem A. M. Farghali1Yue Wu2Ivan El-Sayed3Ahmed H. Osman4Salah A. Selim5Mostafa A. El-Sayed6Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USADepartment of Veterinary Medicine, Cairo University, Giza 12211, EgyptLaser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USADepartment of Otolaryngology, University of California, San Francisco, CA 94115, USADepartment of Veterinary Medicine, Cairo University, Giza 12211, EgyptDepartment of Veterinary Medicine, Cairo University, Giza 12211, EgyptLaser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USAFor localized tumors, gold nanorod (AuNR)-assisted plasmonic photothermal therapy (PPTT) is a potentially effective alternative to traditional surgery, in which AuNRs absorb near-infrared light and convert it to heat in order to kill cancer cells. However, for large tumors (volume ≥ 20 cm<sup>3</sup>), an uneven distribution of AuNRs might cause inhomogeneity of the heat distribution inside the tumor. Surgery is frequently recommended for removing large tumors, but it is associated with a high risk of cancer recurrence and metastasis. Here, we applied PPTT before surgery, which showed improved treatment for large tumors. We divided the animals (eight cats/dogs) into two groups: Group I (control), where three cases were solely treated with surgery, laser, or AuNRs alone, resulting in recurrence and metastasis; and Group II, where animals were treated with PPTT before surgery. In Group II, four out of the five cases had tumor regression without any recurrence or metastasis. Interestingly, we observed that applying PPTT before surgery displayed reduced bleeding during tumor removal, supported by histopathology that showed altered blood vessels. In conclusion, our study showed that applying AuNR-assisted PPTT (AuNRs-PPTT) before surgery could significantly affect blood vessels inside the tumor, leading to a decreased amount of bleeding during surgery, which can potentially decrease the risk of metastasis and blood loss during surgery.https://www.mdpi.com/2072-6694/11/6/851plasmonic photothermal therapygold nanorodssurgerybleedingdogscatsbreast cancer |
| spellingShingle | Moustafa R. K. Ali Haithem A. M. Farghali Yue Wu Ivan El-Sayed Ahmed H. Osman Salah A. Selim Mostafa A. El-Sayed Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats Cancers plasmonic photothermal therapy gold nanorods surgery bleeding dogs cats breast cancer |
| title | Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats |
| title_full | Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats |
| title_fullStr | Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats |
| title_full_unstemmed | Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats |
| title_short | Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats |
| title_sort | gold nanorod assisted photothermal therapy decreases bleeding during breast cancer surgery in dogs and cats |
| topic | plasmonic photothermal therapy gold nanorods surgery bleeding dogs cats breast cancer |
| url | https://www.mdpi.com/2072-6694/11/6/851 |
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