The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines
ObjectiveProlonged sleep onset latency (PSOL) and age have been linked to ischemic stroke (IS) severity and the production of chemokines and inflammation, both of which contribute to IS development. This study aimed to explore the relationship between chemokines, inflammation, and the interplay betw...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1323878/full |
| _version_ | 1797304963115778048 |
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| author | Yuyu Zhou Yuyu Zhou Xiaoli Han Qingshuang Mu Lifei Xing Yan Wu Cunbao Li Yanlong Liu Fan Wang |
| author_facet | Yuyu Zhou Yuyu Zhou Xiaoli Han Qingshuang Mu Lifei Xing Yan Wu Cunbao Li Yanlong Liu Fan Wang |
| author_sort | Yuyu Zhou |
| collection | DOAJ |
| description | ObjectiveProlonged sleep onset latency (PSOL) and age have been linked to ischemic stroke (IS) severity and the production of chemokines and inflammation, both of which contribute to IS development. This study aimed to explore the relationship between chemokines, inflammation, and the interplay between sleep onset latency (SOL) and age in influencing stroke severity.MethodsA cohort of 281 participants with mild to moderate IS was enrolled. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and SOL was recorded. Serum levels of macrophage inflammatory protein-1alpha (MIP-1α), macrophage inflammatory protein-1beta (MIP-1β), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured.ResultsNIHSS scores of middle-aged participants with PSOL were significantly higher than those with normal sleep onset latency (NSOL) (p = 0.046). This difference was also observed when compared to both the elderly with NSOL (p = 0.022), and PSOL (p < 0.001). Among middle-aged adults with PSOL, MIP-1β exhibited a protective effect on NIHSS scores (β = −0.01, t = −2.11, p = 0.039, R2 = 0.13). MIP-1α demonstrated a protective effect on NIHSS scores in the elderly with NSOL (β = −0.03, t = −2.27, p = 0.027, R2 = 0.12).ConclusionThis study reveals a hitherto undocumented association between PSOL and IS severity, along with the potential protective effects of MIP-1β in mitigating stroke severity, especially among middle-aged patients. |
| first_indexed | 2024-03-08T00:18:59Z |
| format | Article |
| id | doaj.art-5a61c479db514c998c4dd58efb81548e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-08T00:18:59Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-5a61c479db514c998c4dd58efb81548e2024-02-16T14:23:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-02-011510.3389/fneur.2024.13238781323878The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokinesYuyu Zhou0Yuyu Zhou1Xiaoli Han2Qingshuang Mu3Lifei Xing4Yan Wu5Cunbao Li6Yanlong Liu7Fan Wang8Beijing Hui-Long-Guan Hospital, Peking University, Beijing, ChinaMedical Neurobiology Lab, Inner Mongolia Medical University, Huhhot, ChinaClinical Nutrition Department, Friendship Hospital of Urumqi, Urumqi, ChinaXinjiang Key Laboratory of Neurological Disorder Research, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Neurology, Sinopharm North Hospital, Baotou, ChinaBeijing Hui-Long-Guan Hospital, Peking University, Beijing, ChinaMedical Neurobiology Lab, Inner Mongolia Medical University, Huhhot, ChinaSchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaBeijing Hui-Long-Guan Hospital, Peking University, Beijing, ChinaObjectiveProlonged sleep onset latency (PSOL) and age have been linked to ischemic stroke (IS) severity and the production of chemokines and inflammation, both of which contribute to IS development. This study aimed to explore the relationship between chemokines, inflammation, and the interplay between sleep onset latency (SOL) and age in influencing stroke severity.MethodsA cohort of 281 participants with mild to moderate IS was enrolled. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and SOL was recorded. Serum levels of macrophage inflammatory protein-1alpha (MIP-1α), macrophage inflammatory protein-1beta (MIP-1β), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured.ResultsNIHSS scores of middle-aged participants with PSOL were significantly higher than those with normal sleep onset latency (NSOL) (p = 0.046). This difference was also observed when compared to both the elderly with NSOL (p = 0.022), and PSOL (p < 0.001). Among middle-aged adults with PSOL, MIP-1β exhibited a protective effect on NIHSS scores (β = −0.01, t = −2.11, p = 0.039, R2 = 0.13). MIP-1α demonstrated a protective effect on NIHSS scores in the elderly with NSOL (β = −0.03, t = −2.27, p = 0.027, R2 = 0.12).ConclusionThis study reveals a hitherto undocumented association between PSOL and IS severity, along with the potential protective effects of MIP-1β in mitigating stroke severity, especially among middle-aged patients.https://www.frontiersin.org/articles/10.3389/fneur.2024.1323878/fullsleep onset latencyageischemic strokeinflammationinteraction |
| spellingShingle | Yuyu Zhou Yuyu Zhou Xiaoli Han Qingshuang Mu Lifei Xing Yan Wu Cunbao Li Yanlong Liu Fan Wang The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines Frontiers in Neurology sleep onset latency age ischemic stroke inflammation interaction |
| title | The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines |
| title_full | The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines |
| title_fullStr | The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines |
| title_full_unstemmed | The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines |
| title_short | The effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines |
| title_sort | effect of the interaction of sleep onset latency and age on ischemic stroke severity via inflammatory chemokines |
| topic | sleep onset latency age ischemic stroke inflammation interaction |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1323878/full |
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