Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise
Different from normal cells, cancer cells must hyperactivate a variety of integrated responses in order to survive their basal stress or its exacerbation caused by exposure to anti-cancer agents. As cancer cells become particularly dependent on these adaptive responses, namely UPR, DDR autophagy, an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/11/2780 |
| _version_ | 1797493844739096576 |
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| author | Gabriella D’Orazi Mara Cirone |
| author_facet | Gabriella D’Orazi Mara Cirone |
| author_sort | Gabriella D’Orazi |
| collection | DOAJ |
| description | Different from normal cells, cancer cells must hyperactivate a variety of integrated responses in order to survive their basal stress or its exacerbation caused by exposure to anti-cancer agents. As cancer cells become particularly dependent on these adaptive responses, namely UPR, DDR autophagy, anti-oxidant and heat shock responses, this turns out to be an Achille’s heel, which allows them to be selectively killed while sparing normal unstressed cells. Better knowledge of the cross-talk between these adaptive processes and their impact on the immune system is needed to design more effective anti-cancer therapies, as reviewed in this paper. |
| first_indexed | 2024-03-10T01:25:48Z |
| format | Article |
| id | doaj.art-5a64cec1d8fb497dbf46e0c1aa2162a0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:25:48Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5a64cec1d8fb497dbf46e0c1aa2162a02023-11-23T13:51:02ZengMDPI AGCancers2072-66942022-06-011411278010.3390/cancers14112780Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular DemiseGabriella D’Orazi0Mara Cirone1Department of Neurosciences, Imaging and Clinical Sciences, University “G. D’Annunzio”, 66013 Chieti, ItalyDepartment of Experimental Medicine, University of Rome LA Sapienza, Viale Regina Elena 324, 00161 Rome, ItalyDifferent from normal cells, cancer cells must hyperactivate a variety of integrated responses in order to survive their basal stress or its exacerbation caused by exposure to anti-cancer agents. As cancer cells become particularly dependent on these adaptive responses, namely UPR, DDR autophagy, anti-oxidant and heat shock responses, this turns out to be an Achille’s heel, which allows them to be selectively killed while sparing normal unstressed cells. Better knowledge of the cross-talk between these adaptive processes and their impact on the immune system is needed to design more effective anti-cancer therapies, as reviewed in this paper.https://www.mdpi.com/2072-6694/14/11/2780ER stressUPRDDRHSPsautophagyanti-oxidant response |
| spellingShingle | Gabriella D’Orazi Mara Cirone Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise Cancers ER stress UPR DDR HSPs autophagy anti-oxidant response |
| title | Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise |
| title_full | Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise |
| title_fullStr | Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise |
| title_full_unstemmed | Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise |
| title_short | Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise |
| title_sort | interconnected adaptive responses a way out for cancer cells to avoid cellular demise |
| topic | ER stress UPR DDR HSPs autophagy anti-oxidant response |
| url | https://www.mdpi.com/2072-6694/14/11/2780 |
| work_keys_str_mv | AT gabrielladorazi interconnectedadaptiveresponsesawayoutforcancercellstoavoidcellulardemise AT maracirone interconnectedadaptiveresponsesawayoutforcancercellstoavoidcellulardemise |