A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction
INTRODUCTION: The increased risk of infection for patients caused by construction and renovation near hematology inpatient clinics is a major concern. The use of high-efficiency particulate absorption (HEPA) filters can reduce the risk of infection. However, there is no standard protocol indicating...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2016-02-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-14477 |
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| author | Mehmet Özen Gülden Yılmaz Belgin Coşkun Pervin Topçuoğlu Bengi Öztürk Mehmet Gündüz Erden Atilla Önder Arslan Muhit Özcan Taner Demirer Osman İlhan Nahide Konuk İsmail Balık Günhan Gürman Hamdi Akan |
| author_facet | Mehmet Özen Gülden Yılmaz Belgin Coşkun Pervin Topçuoğlu Bengi Öztürk Mehmet Gündüz Erden Atilla Önder Arslan Muhit Özcan Taner Demirer Osman İlhan Nahide Konuk İsmail Balık Günhan Gürman Hamdi Akan |
| author_sort | Mehmet Özen |
| collection | DOAJ |
| description | INTRODUCTION: The increased risk of infection for patients caused by construction and renovation near hematology inpatient clinics is a major concern. The use of high-efficiency particulate absorption (HEPA) filters can reduce the risk of infection. However, there is no standard protocol indicating the use of HEPA filters for patients with hematological malignancies, except for those who have undergone allogeneic hematopoietic stem cell transplantation. This quasi-experimental study was designed to measure the efficacy of HEPA filters in preventing infections during construction. METHODS: Portable HEPA filters were placed in the rooms of patients undergoing treatment for hematological malignancies because of large-scale construction taking place near the hematology clinic. The rates of infection during the 6 months before and after the installation of the portable HEPA filters were compared. A total of 413 patients were treated during this 1-year period. RESULTS: There were no significant differences in the antifungal prophylaxis and treatment regimens between the groups. The rates of infections, clinically documented infections, and invasive fungal infections decreased in all of the patients following the installation of the HEPA filters. When analyzed separately, the rates of invasive fungal infections were similar before and after the installation of HEPA filters in patients who had no neutropenia or long neutropenia duration. HEPA filters were significantly protective against infection when installed in the rooms of patients with acute lymphocytic leukemia, patients who were undergoing consolidation treatment, and patients who were neutropenic for 1-14 days. DISCUSSION AND CONCLUSION: Despite the advent of construction and the summer season, during which environmental Aspergillus contamination is more prevalent, no patient or patient subgroup experienced an increase in fungal infections following the installation of HEPA filters. The protective effect of HEPA filters against infection was more pronounced in patients with acute lymphocytic leukemia, patients undergoing consolidation therapy, and patients with moderate neutropenia. |
| first_indexed | 2024-04-10T14:21:46Z |
| format | Article |
| id | doaj.art-5a6680d114b84402ab0a22ae905fb320 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T14:21:46Z |
| publishDate | 2016-02-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-5a6680d114b84402ab0a22ae905fb3202023-02-15T16:09:16ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632016-02-01331414710.4274/tjh.2014.0010TJH-14477A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during ConstructionMehmet Özen0Gülden Yılmaz1Belgin Coşkun2Pervin Topçuoğlu3Bengi Öztürk4Mehmet Gündüz5Erden Atilla6Önder Arslan7Muhit Özcan8Taner Demirer9Osman İlhan10Nahide Konuk11İsmail Balık12Günhan Gürman13Hamdi Akan14Ankara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Infectious Diseases, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Infectious Diseases, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Internal Medicine, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Infectious Diseases, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Hematology, Ankara, TurkeyINTRODUCTION: The increased risk of infection for patients caused by construction and renovation near hematology inpatient clinics is a major concern. The use of high-efficiency particulate absorption (HEPA) filters can reduce the risk of infection. However, there is no standard protocol indicating the use of HEPA filters for patients with hematological malignancies, except for those who have undergone allogeneic hematopoietic stem cell transplantation. This quasi-experimental study was designed to measure the efficacy of HEPA filters in preventing infections during construction. METHODS: Portable HEPA filters were placed in the rooms of patients undergoing treatment for hematological malignancies because of large-scale construction taking place near the hematology clinic. The rates of infection during the 6 months before and after the installation of the portable HEPA filters were compared. A total of 413 patients were treated during this 1-year period. RESULTS: There were no significant differences in the antifungal prophylaxis and treatment regimens between the groups. The rates of infections, clinically documented infections, and invasive fungal infections decreased in all of the patients following the installation of the HEPA filters. When analyzed separately, the rates of invasive fungal infections were similar before and after the installation of HEPA filters in patients who had no neutropenia or long neutropenia duration. HEPA filters were significantly protective against infection when installed in the rooms of patients with acute lymphocytic leukemia, patients who were undergoing consolidation treatment, and patients who were neutropenic for 1-14 days. DISCUSSION AND CONCLUSION: Despite the advent of construction and the summer season, during which environmental Aspergillus contamination is more prevalent, no patient or patient subgroup experienced an increase in fungal infections following the installation of HEPA filters. The protective effect of HEPA filters against infection was more pronounced in patients with acute lymphocytic leukemia, patients undergoing consolidation therapy, and patients with moderate neutropenia.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-14477hepa filterinfectioninvasive fungal infection |
| spellingShingle | Mehmet Özen Gülden Yılmaz Belgin Coşkun Pervin Topçuoğlu Bengi Öztürk Mehmet Gündüz Erden Atilla Önder Arslan Muhit Özcan Taner Demirer Osman İlhan Nahide Konuk İsmail Balık Günhan Gürman Hamdi Akan A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction Turkish Journal of Hematology hepa filter infection invasive fungal infection |
| title | A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction |
| title_full | A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction |
| title_fullStr | A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction |
| title_full_unstemmed | A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction |
| title_short | A Quasi-Experimental Study Analyzing the Effectiveness of Portable High-Efficiency Particulate Absorption Filters in Preventing Infections in Hematology Patients during Construction |
| title_sort | quasi experimental study analyzing the effectiveness of portable high efficiency particulate absorption filters in preventing infections in hematology patients during construction |
| topic | hepa filter infection invasive fungal infection |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-14477 |
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