Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

Precision gene editing in primary hematopoietic stem and progenitor cells (HSPCs) would facilitate both curative treatments for monogenic disorders as well as disease modelling. Precise efficiencies even with the CRISPR/Cas system, however, remain limited. Through an optimization of guide RNA delive...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Fanny-Mei Cloarec-Ung, Jamie Beaulieu, Arunan Suthananthan, Bernhard Lehnertz, Guy Sauvageau, Hilary M Sheppard, David JHF Knapp
Formatua:	Artikulua
Hizkuntza:	English
Argitaratua:	eLife Sciences Publications Ltd 2024-06-01
Saila:	eLife
Gaiak:	stem cell hematopoiesis genome editing CRISPR hematopoietic stem cell leukemia
Sarrera elektronikoa:	https://elifesciences.org/articles/91288

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