Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients
Abstract We aimed to analyze whether opisthenar microvessel area (OMA, measured with Optical Coherence Tomography (OCT) angiography) was associated with blood pressure (BP), arterial stiffness and whether OMA can predict arterial stiffness in hypertensive (HTN) patients. Results from 90 participants...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02294-z |
| _version_ | 1818459033669992448 |
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| author | Zhen Yi Guo Chen Chen Xin Jin Zai Hao Zhao Lan Cui Yin Hua Zhang |
| author_facet | Zhen Yi Guo Chen Chen Xin Jin Zai Hao Zhao Lan Cui Yin Hua Zhang |
| author_sort | Zhen Yi Guo |
| collection | DOAJ |
| description | Abstract We aimed to analyze whether opisthenar microvessel area (OMA, measured with Optical Coherence Tomography (OCT) angiography) was associated with blood pressure (BP), arterial stiffness and whether OMA can predict arterial stiffness in hypertensive (HTN) patients. Results from 90 participants showed that BP, brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were significantly higher but OMA (in control, with cold- and warm-stimulation, NT, CST, HST and the differences, CSD, HSD) were significantly reduced in HTN group (n = 36) compared to non-HTN (n = 54). NT, CST, HST and HSD showed negative correlations with baPWV and ABI in all participants, female (n = 47) and male group (n = 43), but the correlation was absent when the participants were divided into HTN and non-HTN. Logistic Regression analysis showed that only baPWV was a significant risk factor for HSD (OR 19.7, 95%CI 4.959–78.733, p < 0.0001) but not the age, BMI, smoking, drinking or exercise status (p > 0.05). Receiver Operating Characteristics analysis for HSD was 0.781, 0.804, 0.770, respectively. HSD < 9439.5 μm2 predicted high BP and arterial stiffness (95% CI in all participants: baPWV, 0.681–0.881, SBP, 0.709–0.900, DBP, 0.672–0.867, p < 0.001). These results suggest that OMA is a sensitive index to predict arterial stiffness in HTN population. |
| first_indexed | 2024-12-14T23:07:55Z |
| format | Article |
| id | doaj.art-5a69bced8011407697cc65b9ab98ea1d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T23:07:55Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5a69bced8011407697cc65b9ab98ea1d2022-12-21T22:44:17ZengNature PortfolioScientific Reports2045-23222021-12-0111111410.1038/s41598-021-02294-zOpisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patientsZhen Yi Guo0Chen Chen1Xin Jin2Zai Hao Zhao3Lan Cui4Yin Hua Zhang5Yanbian University HospitalYanbian University HospitalYanbian University HospitalYanbian University HospitalYanbian University HospitalYanbian University HospitalAbstract We aimed to analyze whether opisthenar microvessel area (OMA, measured with Optical Coherence Tomography (OCT) angiography) was associated with blood pressure (BP), arterial stiffness and whether OMA can predict arterial stiffness in hypertensive (HTN) patients. Results from 90 participants showed that BP, brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were significantly higher but OMA (in control, with cold- and warm-stimulation, NT, CST, HST and the differences, CSD, HSD) were significantly reduced in HTN group (n = 36) compared to non-HTN (n = 54). NT, CST, HST and HSD showed negative correlations with baPWV and ABI in all participants, female (n = 47) and male group (n = 43), but the correlation was absent when the participants were divided into HTN and non-HTN. Logistic Regression analysis showed that only baPWV was a significant risk factor for HSD (OR 19.7, 95%CI 4.959–78.733, p < 0.0001) but not the age, BMI, smoking, drinking or exercise status (p > 0.05). Receiver Operating Characteristics analysis for HSD was 0.781, 0.804, 0.770, respectively. HSD < 9439.5 μm2 predicted high BP and arterial stiffness (95% CI in all participants: baPWV, 0.681–0.881, SBP, 0.709–0.900, DBP, 0.672–0.867, p < 0.001). These results suggest that OMA is a sensitive index to predict arterial stiffness in HTN population.https://doi.org/10.1038/s41598-021-02294-z |
| spellingShingle | Zhen Yi Guo Chen Chen Xin Jin Zai Hao Zhao Lan Cui Yin Hua Zhang Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients Scientific Reports |
| title | Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients |
| title_full | Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients |
| title_fullStr | Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients |
| title_full_unstemmed | Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients |
| title_short | Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients |
| title_sort | opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients |
| url | https://doi.org/10.1038/s41598-021-02294-z |
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