Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death.

Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death.

The Tyro3, Axl and Mertk (TAM) triply knockout (TKO) mice exhibit systemic autoimmune diseases, with characteristics of increased proinflammatory cytokine production, autoantibody deposition and autoreactive lymphocyte infiltration into a variety of tissues. Here we show that TKO mice produce high l...

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Bibliographic Details
Main Authors: Qiutang Li, Qingjun Lu, Huayi Lu, Shifu Tian, Qingxian Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3688737?pdf=render

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