Anticoagulant activities of curcumin and its derivative
Curcumin, a polyphenol responsible for the yellow color ofthe curry spice turmeric, possesses antiinflammatory, antiproliferativeand antiangiogenic activities. However, anticoagulantactivities of curcumin have not been studied. Here,the anticoagulant properties of curcumin and its derivative(bisdeme...
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2012-04-01
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| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS00JTVEMTIwNDI2MTkwMF8lMjgyMjEtMjI2JTI5Qk1CMTEtMTQ2LnBkZg== |
| _version_ | 1818935591874592768 |
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| author | Dong-Chan Kim Sae-Kwang Ku Jong-Sup Bae |
| author_facet | Dong-Chan Kim Sae-Kwang Ku Jong-Sup Bae |
| author_sort | Dong-Chan Kim |
| collection | DOAJ |
| description | Curcumin, a polyphenol responsible for the yellow color ofthe curry spice turmeric, possesses antiinflammatory, antiproliferativeand antiangiogenic activities. However, anticoagulantactivities of curcumin have not been studied. Here,the anticoagulant properties of curcumin and its derivative(bisdemethoxycurcumin, BDMC) were determined by monitoringactivated partial thromboplastin time (aPTT), prothrombintime (PT) as well as cell-based thrombin and activated factor X(FXa) generation activities. Data showed that curcumin andBDMC prolonged aPTT and PT significantly and inhibitedthrombin and FXa activities. They inhibited the generation ofthrombin or FXa. In accordance with these anticoagulant activities,curcumin and BDMC showed anticoagulant effect invivo. Surprisingly, these anticoagulant effects of curcuminwere better than those of BDMC indicating that methoxygroup in curcumin positively regulated anticoagulant functionof curcumin. Therefore, these results suggest that curcuminand BDMC possess antithrombotic activities and daily consumptionof the curry spice turmeric might help maintain anticoagulantstatus. [BMB reports 2012; 45(4): 221-226] |
| first_indexed | 2024-12-20T05:22:37Z |
| format | Article |
| id | doaj.art-5a6c8481e40f4cbda4277ed0e517f83e |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-12-20T05:22:37Z |
| publishDate | 2012-04-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-5a6c8481e40f4cbda4277ed0e517f83e2022-12-21T19:51:57ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2012-04-01454221226http://dx.doi.org/10.5483/BMBRep.2012.45.4.221Anticoagulant activities of curcumin and its derivativeDong-Chan KimSae-Kwang KuJong-Sup BaeCurcumin, a polyphenol responsible for the yellow color ofthe curry spice turmeric, possesses antiinflammatory, antiproliferativeand antiangiogenic activities. However, anticoagulantactivities of curcumin have not been studied. Here,the anticoagulant properties of curcumin and its derivative(bisdemethoxycurcumin, BDMC) were determined by monitoringactivated partial thromboplastin time (aPTT), prothrombintime (PT) as well as cell-based thrombin and activated factor X(FXa) generation activities. Data showed that curcumin andBDMC prolonged aPTT and PT significantly and inhibitedthrombin and FXa activities. They inhibited the generation ofthrombin or FXa. In accordance with these anticoagulant activities,curcumin and BDMC showed anticoagulant effect invivo. Surprisingly, these anticoagulant effects of curcuminwere better than those of BDMC indicating that methoxygroup in curcumin positively regulated anticoagulant functionof curcumin. Therefore, these results suggest that curcuminand BDMC possess antithrombotic activities and daily consumptionof the curry spice turmeric might help maintain anticoagulantstatus. [BMB reports 2012; 45(4): 221-226]http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS00JTVEMTIwNDI2MTkwMF8lMjgyMjEtMjI2JTI5Qk1CMTEtMTQ2LnBkZg==aPTTCurcuminHUVECsPT |
| spellingShingle | Dong-Chan Kim Sae-Kwang Ku Jong-Sup Bae Anticoagulant activities of curcumin and its derivative BMB Reports aPTT Curcumin HUVECs PT |
| title | Anticoagulant activities of curcumin and its derivative |
| title_full | Anticoagulant activities of curcumin and its derivative |
| title_fullStr | Anticoagulant activities of curcumin and its derivative |
| title_full_unstemmed | Anticoagulant activities of curcumin and its derivative |
| title_short | Anticoagulant activities of curcumin and its derivative |
| title_sort | anticoagulant activities of curcumin and its derivative |
| topic | aPTT Curcumin HUVECs PT |
| url | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS00JTVEMTIwNDI2MTkwMF8lMjgyMjEtMjI2JTI5Qk1CMTEtMTQ2LnBkZg== |
| work_keys_str_mv | AT dongchankim anticoagulantactivitiesofcurcuminanditsderivative AT saekwangku anticoagulantactivitiesofcurcuminanditsderivative AT jongsupbae anticoagulantactivitiesofcurcuminanditsderivative |