Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the Disease
OBJECTIVE: To measure serum testosterone levels in type-II diabetes mellitus male subjects and to correlate its association with blood glycated haemoglobin A1 (HbA1C) levels and - duration of the disease. METHODOLOGY: This cross sectional study was carried out at Biochemistry department, LUMHS, Jam...
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| Format: | Article |
| Language: | English |
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Liaquat University of Medical and Health Sciences
2021-03-01
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| Series: | JLUMHS |
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| _version_ | 1798027596255985664 |
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| author | Mubeena Laghari Fozia Shaikh Shazia Murtaza Munazzah Meraj Farah Shaikh |
| author_facet | Mubeena Laghari Fozia Shaikh Shazia Murtaza Munazzah Meraj Farah Shaikh |
| author_sort | Mubeena Laghari |
| collection | DOAJ |
| description | OBJECTIVE: To measure serum testosterone levels in type-II diabetes mellitus male subjects and to correlate its association with blood glycated haemoglobin A1 (HbA1C) levels and - duration of the disease.
METHODOLOGY: This cross sectional study was carried out at Biochemistry department, LUMHS, Jamshoro, from December 2015 to May 2016. One hundred male subjects including 50 DM patients and 50 age matched with no family history of DM, were enrolled by purposive sampling technique. Study population excluded those patients diagnosed as diabetic erectile dysfunction, diabetic nephropathy, diabetic renal failure, metformin therapy, familial dyslipidemia, and hypercholesterolemia. Serum testosterone (ELISA assay) and whole blood HbA1C levels (TINIA assay) were measured by standard laboratory methods using Hitachi Roche Diagnostic Chemistry Analyzer. The obtained results were analysed by SPSS version 21.0(IBM, Incorporation, and USA) and is reported as Mean± SD. The p ≤ 0.05 was considered to indicate statistical significance.
RESULTS: The ages of diabetes mellitus patients and control subjects were 58.24±11.13 and 54.56±10.44 years respectively. Serum testosterone levels were observed to be more significant (p<0.004) in control subjects (3.53±0.74 mg /dL) and its levels decreased in diabetes mellitus patients (2.53±1.13 mg /dL). Similarly, HbA1C levels were significantly higher (p<0.0001) in diabetic subjects as compared to control subjects (8.40±1.27 vs 5.75±0.24%). Testosterone levels showed negative correlation with blood HbA1C levels and positive with duration of disease.
CONCLUSION: In type 2 diabetic male patients serum testosterone levels demonstrated negative correlation with blood HbA1C levels and positive with duration of DM. |
| first_indexed | 2024-04-11T18:54:01Z |
| format | Article |
| id | doaj.art-5a6e9190f3ab416283faf9d2a0ed5b78 |
| institution | Directory Open Access Journal |
| issn | 1729-0341 2309-8627 |
| language | English |
| last_indexed | 2024-04-11T18:54:01Z |
| publishDate | 2021-03-01 |
| publisher | Liaquat University of Medical and Health Sciences |
| record_format | Article |
| series | JLUMHS |
| spelling | doaj.art-5a6e9190f3ab416283faf9d2a0ed5b782022-12-22T04:08:15ZengLiaquat University of Medical and Health SciencesJLUMHS1729-03412309-86272021-03-01201374110.22442/jlumhs.2021.00674Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the DiseaseMubeena Laghari 0Fozia Shaikh 1Shazia Murtaza 2Munazzah Meraj 3Farah Shaikh 4Associate Professor Department of Biochemistry Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Sindh-Pakistan.Lecturer, Department of Biochemistry LUMHS, Jamshoro, Sindh-Pakistan.Clinical trial unit Research Specialist Prince Naif Health Research Centre King Saud University Medical City, Riyadh KSA.Associate Professor (PhD Biochemistry) Department of Biochemistry Peoples University of Medical and Health Sciences for women Nawabshah, Sindh-Pakistan.Lecturer, Department of Community Medicine LUMHS, Jamshoro, Sindh-Pakistan. OBJECTIVE: To measure serum testosterone levels in type-II diabetes mellitus male subjects and to correlate its association with blood glycated haemoglobin A1 (HbA1C) levels and - duration of the disease. METHODOLOGY: This cross sectional study was carried out at Biochemistry department, LUMHS, Jamshoro, from December 2015 to May 2016. One hundred male subjects including 50 DM patients and 50 age matched with no family history of DM, were enrolled by purposive sampling technique. Study population excluded those patients diagnosed as diabetic erectile dysfunction, diabetic nephropathy, diabetic renal failure, metformin therapy, familial dyslipidemia, and hypercholesterolemia. Serum testosterone (ELISA assay) and whole blood HbA1C levels (TINIA assay) were measured by standard laboratory methods using Hitachi Roche Diagnostic Chemistry Analyzer. The obtained results were analysed by SPSS version 21.0(IBM, Incorporation, and USA) and is reported as Mean± SD. The p ≤ 0.05 was considered to indicate statistical significance. RESULTS: The ages of diabetes mellitus patients and control subjects were 58.24±11.13 and 54.56±10.44 years respectively. Serum testosterone levels were observed to be more significant (p<0.004) in control subjects (3.53±0.74 mg /dL) and its levels decreased in diabetes mellitus patients (2.53±1.13 mg /dL). Similarly, HbA1C levels were significantly higher (p<0.0001) in diabetic subjects as compared to control subjects (8.40±1.27 vs 5.75±0.24%). Testosterone levels showed negative correlation with blood HbA1C levels and positive with duration of disease. CONCLUSION: In type 2 diabetic male patients serum testosterone levels demonstrated negative correlation with blood HbA1C levels and positive with duration of DM.serum testosteronetype 2 diabetes mellitus |
| spellingShingle | Mubeena Laghari Fozia Shaikh Shazia Murtaza Munazzah Meraj Farah Shaikh Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the Disease JLUMHS serum testosterone type 2 diabetes mellitus |
| title | Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the Disease |
| title_full | Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the Disease |
| title_fullStr | Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the Disease |
| title_full_unstemmed | Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the Disease |
| title_short | Testosterone Levels in Male Type-II Diabetic Patients and its Association with HBA1C Levels and Duration of the Disease |
| title_sort | testosterone levels in male type ii diabetic patients and its association with hba1c levels and duration of the disease |
| topic | serum testosterone type 2 diabetes mellitus |
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