STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
Summary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics regulated by mitochondria-localized nuclear TFs are...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222011956 |
| _version_ | 1811281156071489536 |
|---|---|
| author | Hyunmi Kim Soo Jung Park Ilo Jou |
| author_facet | Hyunmi Kim Soo Jung Park Ilo Jou |
| author_sort | Hyunmi Kim |
| collection | DOAJ |
| description | Summary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics regulated by mitochondria-localized nuclear TFs are yet to be fully characterized. Here, we identify STAT6 as a mitochondrial protein that is localized in the outer membrane of mitochondria (OMM). STAT6 in OMM inhibits mitochondrial fusion by blocking MFN2 dimerization. This implies that STAT6 has a critical role in mitochondrial dynamics. Moreover, mitochondrial accumulation of STAT6 in response to hypoxic conditions reveals that STAT6 is a regulator of mitochondrial processes including fusion/fission mechanisms. |
| first_indexed | 2024-04-13T01:27:33Z |
| format | Article |
| id | doaj.art-5a6ea2ac09044c75a4c2893214310914 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-13T01:27:33Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-5a6ea2ac09044c75a4c28932143109142022-12-22T03:08:35ZengElsevieriScience2589-00422022-09-01259104923STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerizationHyunmi Kim0Soo Jung Park1Ilo Jou2Department of Pharmacology, Inflammaging Translational Research Center, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon 16499, Korea; AI Superconvergence KIURI Translational Research Center, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Pharmacology, Inflammaging Translational Research Center, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon 16499, KoreaDepartment of Pharmacology, Inflammaging Translational Research Center, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon 16499, Korea; Corresponding authorSummary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics regulated by mitochondria-localized nuclear TFs are yet to be fully characterized. Here, we identify STAT6 as a mitochondrial protein that is localized in the outer membrane of mitochondria (OMM). STAT6 in OMM inhibits mitochondrial fusion by blocking MFN2 dimerization. This implies that STAT6 has a critical role in mitochondrial dynamics. Moreover, mitochondrial accumulation of STAT6 in response to hypoxic conditions reveals that STAT6 is a regulator of mitochondrial processes including fusion/fission mechanisms.http://www.sciencedirect.com/science/article/pii/S2589004222011956Natural sciencesBiological sciencesMolecular biologyMolecular interaction |
| spellingShingle | Hyunmi Kim Soo Jung Park Ilo Jou STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization iScience Natural sciences Biological sciences Molecular biology Molecular interaction |
| title | STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization |
| title_full | STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization |
| title_fullStr | STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization |
| title_full_unstemmed | STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization |
| title_short | STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization |
| title_sort | stat6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting mfn2 dimerization |
| topic | Natural sciences Biological sciences Molecular biology Molecular interaction |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222011956 |
| work_keys_str_mv | AT hyunmikim stat6inmitochondrialoutermembraneimpairsmitochondrialfusionbyinhibitingmfn2dimerization AT soojungpark stat6inmitochondrialoutermembraneimpairsmitochondrialfusionbyinhibitingmfn2dimerization AT ilojou stat6inmitochondrialoutermembraneimpairsmitochondrialfusionbyinhibitingmfn2dimerization |