Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats
The walnut green husk has antibacterial, anti-oxidant, anti-inflammatory and other biological activities, but its lipid-lowering activity has not been reported. This study investigated the effects of walnut green husk extract (WGH) on lipid levels and gut bacteria flora in obese rats induced by high...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461830598X |
| _version_ | 1818406192235413504 |
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| author | Xiaoshuang Wang Dan Chen Yulan Li Shenglan Zhao Chaoyin Chen Delu Ning |
| author_facet | Xiaoshuang Wang Dan Chen Yulan Li Shenglan Zhao Chaoyin Chen Delu Ning |
| author_sort | Xiaoshuang Wang |
| collection | DOAJ |
| description | The walnut green husk has antibacterial, anti-oxidant, anti-inflammatory and other biological activities, but its lipid-lowering activity has not been reported. This study investigated the effects of walnut green husk extract (WGH) on lipid levels and gut bacteria flora in obese rats induced by high-fat diet. The results showed that WGH significantly reduced body weight gain, reversed liver TC, TG, LDL-C, HDL-C, MDA, ALT, AST and serum TC, TG, LDL-C, MDA, leptin levels, insulin resistance and glucose tolerance in high fat diet-induced obesity rats. Meanwhile, fat accumulation, hepatic steatosis and adipose tissue hypertrophy of HFD were reduced by WGH. 16S rRNA sequencing demonstrated that WGH dramaticlly reversed the disorders of gut bacteria flora HFD-induced, reduced the relative abundance of Fusobacteria, Firmicutes and enhanced the relative abundance of Bacteroidetes at the phylum level, reduced the relative abundance of and Peptostreptococcaceae at the family level, furthermore, reduced the relative abundance of Romboutsia, Lachnoclostridium and increased the relative abundance of Bacteroides at the genus level. In conclusion, these beneficial effects of WGH on reducing obesity and lipid disorders could be associated with the modulation of the gut bacteria. |
| first_indexed | 2024-12-14T09:08:02Z |
| format | Article |
| id | doaj.art-5a6ffd8ef8274d52a7f2f5d1a9589057 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T09:08:02Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-5a6ffd8ef8274d52a7f2f5d1a95890572022-12-21T23:08:39ZengElsevierJournal of Functional Foods1756-46462019-01-0152576586Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity ratsXiaoshuang Wang0Dan Chen1Yulan Li2Shenglan Zhao3Chaoyin Chen4Delu Ning5Yunnan University of Traditional Chinese Medicine, Kunming 650500, ChinaYunnan Institute of Tobacco Quality Inspection and Supervision, Kunming 650106, ChinaYunnan University of Traditional Chinese Medicine, Kunming 650500, ChinaYunnan University of Traditional Chinese Medicine, Kunming 650500, China; Corresponding author.Yunnan Academy of Forestry, Kunming 650204, ChinaYunnan Academy of Forestry, Kunming 650204, ChinaThe walnut green husk has antibacterial, anti-oxidant, anti-inflammatory and other biological activities, but its lipid-lowering activity has not been reported. This study investigated the effects of walnut green husk extract (WGH) on lipid levels and gut bacteria flora in obese rats induced by high-fat diet. The results showed that WGH significantly reduced body weight gain, reversed liver TC, TG, LDL-C, HDL-C, MDA, ALT, AST and serum TC, TG, LDL-C, MDA, leptin levels, insulin resistance and glucose tolerance in high fat diet-induced obesity rats. Meanwhile, fat accumulation, hepatic steatosis and adipose tissue hypertrophy of HFD were reduced by WGH. 16S rRNA sequencing demonstrated that WGH dramaticlly reversed the disorders of gut bacteria flora HFD-induced, reduced the relative abundance of Fusobacteria, Firmicutes and enhanced the relative abundance of Bacteroidetes at the phylum level, reduced the relative abundance of and Peptostreptococcaceae at the family level, furthermore, reduced the relative abundance of Romboutsia, Lachnoclostridium and increased the relative abundance of Bacteroides at the genus level. In conclusion, these beneficial effects of WGH on reducing obesity and lipid disorders could be associated with the modulation of the gut bacteria.http://www.sciencedirect.com/science/article/pii/S175646461830598XWalnut green huskExtractsObesityGut bacteria |
| spellingShingle | Xiaoshuang Wang Dan Chen Yulan Li Shenglan Zhao Chaoyin Chen Delu Ning Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats Journal of Functional Foods Walnut green husk Extracts Obesity Gut bacteria |
| title | Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats |
| title_full | Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats |
| title_fullStr | Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats |
| title_full_unstemmed | Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats |
| title_short | Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats |
| title_sort | alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet induced obesity rats |
| topic | Walnut green husk Extracts Obesity Gut bacteria |
| url | http://www.sciencedirect.com/science/article/pii/S175646461830598X |
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