Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines

Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines

The first acyl-coenzyme A:cholesterol acyltransferase (ACAT) cDNA cloned and expressed in 1993 is designated as ACAT-1. In various human tissue homogenates, ACAT-1 protein is effectively solubilized with retention of enzymatic activity by the detergent CHAPS along with high salt. After using anti-AC...

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Bibliographic Details
Main Authors: Oneil Lee, Catherine C.Y. Chang, William Lee, Ta-Yuan Chang
Format: Article
Language:English
Published: Elsevier 1998-08-01
Series:Journal of Lipid Research
Subjects:
cholesteryl esters
hepatocytes
membrane protein solubilization
detergents
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322033

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