Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT

Background. Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid hormone. [18F]-fluorocholine (FCH), PET marker of cellular proliferation, was recently demonstrated to accumulate in lesions representing enla...

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Main Authors: Rep Sebastijan, Lezaic Luka, Kocjan Tomaz, Pfeifer Marija, Sever Mojca Jensterle, Simoncic Urban, Tomse Petra, Hocevar Marko
Format: Article
Language:English
Published: Sciendo 2015-12-01
Series:Radiology and Oncology
Subjects:
Online Access:https://doi.org/10.1515/raon-2015-0016
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author Rep Sebastijan
Lezaic Luka
Kocjan Tomaz
Pfeifer Marija
Sever Mojca Jensterle
Simoncic Urban
Tomse Petra
Hocevar Marko
author_facet Rep Sebastijan
Lezaic Luka
Kocjan Tomaz
Pfeifer Marija
Sever Mojca Jensterle
Simoncic Urban
Tomse Petra
Hocevar Marko
author_sort Rep Sebastijan
collection DOAJ
description Background. Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid hormone. [18F]-fluorocholine (FCH), PET marker of cellular proliferation, was recently demonstrated to accumulate in lesions representing enlarged parathyroid tissue; however, the optimal time to perform FCH PET/CT after FCH administration is not known. The aim of this study was to determine the optimal scan time of FCH PET/CT in patients with primary hyperparathyroidism.
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spelling doaj.art-5a716a24bcc241fab82feb677357c8a52022-12-21T18:36:49ZengSciendoRadiology and Oncology1581-32072015-12-0149432733310.1515/raon-2015-0016raon-2015-0016Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CTRep Sebastijan0Lezaic Luka1Kocjan Tomaz2Pfeifer Marija3Sever Mojca Jensterle4Simoncic Urban5Tomse Petra6Hocevar Marko7 Department for Nuclear Medicine, University Medical Centre Ljubljana, Slovenia Department for Nuclear Medicine, University Medical Centre Ljubljana, Slovenia Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Slovenia Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Slovenia Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Slovenia Jozef Stefan Institute, Ljubljana, Slovenia Department for Nuclear Medicine, University Medical Centre Ljubljana, Slovenia Department of Oncological Surgery, Institute of Oncology Ljubljana, Ljubljana, SloveniaBackground. Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid hormone. [18F]-fluorocholine (FCH), PET marker of cellular proliferation, was recently demonstrated to accumulate in lesions representing enlarged parathyroid tissue; however, the optimal time to perform FCH PET/CT after FCH administration is not known. The aim of this study was to determine the optimal scan time of FCH PET/CT in patients with primary hyperparathyroidism.https://doi.org/10.1515/raon-2015-0016[18f]-fluorocholine pet/ctlesions representing enlarged parathyroid tissuetriple-phasestandardized up-take valueretention indexlesion contrast
spellingShingle Rep Sebastijan
Lezaic Luka
Kocjan Tomaz
Pfeifer Marija
Sever Mojca Jensterle
Simoncic Urban
Tomse Petra
Hocevar Marko
Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT
Radiology and Oncology
[18f]-fluorocholine pet/ct
lesions representing enlarged parathyroid tissue
triple-phase
standardized up-take value
retention index
lesion contrast
title Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT
title_full Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT
title_fullStr Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT
title_full_unstemmed Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT
title_short Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT
title_sort optimal scan time for evaluation of parathyroid adenoma with 18f fluorocholine pet ct
topic [18f]-fluorocholine pet/ct
lesions representing enlarged parathyroid tissue
triple-phase
standardized up-take value
retention index
lesion contrast
url https://doi.org/10.1515/raon-2015-0016
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