Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications
In the present study, chitosan (CS) and pectin (PEC) were utilized for the preparation of 3D printable inks through pneumatic extrusion for biomedical applications. CS is a polysaccharide with beneficial properties; however, its printing behavior is not satisfying, rendering the addition of a thicke...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/19/1/36 |
| _version_ | 1797411222708027392 |
|---|---|
| author | Georgia Michailidou Zoe Terzopoulou Argyroula Kehagia Anna Michopoulou Dimitrios N. Bikiaris |
| author_facet | Georgia Michailidou Zoe Terzopoulou Argyroula Kehagia Anna Michopoulou Dimitrios N. Bikiaris |
| author_sort | Georgia Michailidou |
| collection | DOAJ |
| description | In the present study, chitosan (CS) and pectin (PEC) were utilized for the preparation of 3D printable inks through pneumatic extrusion for biomedical applications. CS is a polysaccharide with beneficial properties; however, its printing behavior is not satisfying, rendering the addition of a thickening agent necessary, i.e., PEC. The influence of PEC in the prepared inks was assessed through rheological measurements, altering the viscosity of the inks to be suitable for 3D printing. 3D printing conditions were optimized and the effect of different drying procedures, along with the presence or absence of a gelating agent on the CS-PEC printed scaffolds were assessed. The mean pore size along with the average filament diameter were measured through SEM micrographs. Interactions among the characteristic groups of the two polymers were evident through FTIR spectra. Swelling and hydrolysis measurements confirmed the influence of gelation and drying procedure on the subsequent behavior of the scaffolds. Ascribed to the beneficial pore size and swelling behavior, fibroblasts were able to survive upon exposure to the ungelated scaffolds. |
| first_indexed | 2024-03-09T04:41:52Z |
| format | Article |
| id | doaj.art-5a74cb4f73bd41de85602305c7faac36 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T04:41:52Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-5a74cb4f73bd41de85602305c7faac362023-12-03T13:19:35ZengMDPI AGMarine Drugs1660-33972021-01-011913610.3390/md19010036Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical ApplicationsGeorgia Michailidou0Zoe Terzopoulou1Argyroula Kehagia2Anna Michopoulou3Dimitrios N. Bikiaris4Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 555 35 Thessaloniki, GreeceLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 555 35 Thessaloniki, GreeceLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 555 35 Thessaloniki, GreeceBiohellenika Biotechnology Company, Leoforos Georgikis Scholis 65, 555 35 Thessaloniki, GreeceLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 555 35 Thessaloniki, GreeceIn the present study, chitosan (CS) and pectin (PEC) were utilized for the preparation of 3D printable inks through pneumatic extrusion for biomedical applications. CS is a polysaccharide with beneficial properties; however, its printing behavior is not satisfying, rendering the addition of a thickening agent necessary, i.e., PEC. The influence of PEC in the prepared inks was assessed through rheological measurements, altering the viscosity of the inks to be suitable for 3D printing. 3D printing conditions were optimized and the effect of different drying procedures, along with the presence or absence of a gelating agent on the CS-PEC printed scaffolds were assessed. The mean pore size along with the average filament diameter were measured through SEM micrographs. Interactions among the characteristic groups of the two polymers were evident through FTIR spectra. Swelling and hydrolysis measurements confirmed the influence of gelation and drying procedure on the subsequent behavior of the scaffolds. Ascribed to the beneficial pore size and swelling behavior, fibroblasts were able to survive upon exposure to the ungelated scaffolds.https://www.mdpi.com/1660-3397/19/1/363D printingchitosanpectinhydrogels |
| spellingShingle | Georgia Michailidou Zoe Terzopoulou Argyroula Kehagia Anna Michopoulou Dimitrios N. Bikiaris Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications Marine Drugs 3D printing chitosan pectin hydrogels |
| title | Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications |
| title_full | Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications |
| title_fullStr | Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications |
| title_full_unstemmed | Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications |
| title_short | Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications |
| title_sort | preliminary evaluation of 3d printed chitosan pectin constructs for biomedical applications |
| topic | 3D printing chitosan pectin hydrogels |
| url | https://www.mdpi.com/1660-3397/19/1/36 |
| work_keys_str_mv | AT georgiamichailidou preliminaryevaluationof3dprintedchitosanpectinconstructsforbiomedicalapplications AT zoeterzopoulou preliminaryevaluationof3dprintedchitosanpectinconstructsforbiomedicalapplications AT argyroulakehagia preliminaryevaluationof3dprintedchitosanpectinconstructsforbiomedicalapplications AT annamichopoulou preliminaryevaluationof3dprintedchitosanpectinconstructsforbiomedicalapplications AT dimitriosnbikiaris preliminaryevaluationof3dprintedchitosanpectinconstructsforbiomedicalapplications |