Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis.
<h4>Background</h4>Frailty has emerged as an important prognostic marker of adverse outcomes after cardiac surgery, but evidence regarding its ability to predict quality of life after cardiac surgery is currently lacking. Whether frail patients derive the same quality of life benefit aft...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0262742 |
| _version_ | 1818986445826686976 |
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| author | Kathryn Bezzina Christophe A Fehlmann Ming Hao Guo Sarah M Visintini Fraser D Rubens George A Wells Rosetta Mazzola Caroline McGuinty Allen Huang Lara Khoury Kevin Emery Boczar |
| author_facet | Kathryn Bezzina Christophe A Fehlmann Ming Hao Guo Sarah M Visintini Fraser D Rubens George A Wells Rosetta Mazzola Caroline McGuinty Allen Huang Lara Khoury Kevin Emery Boczar |
| author_sort | Kathryn Bezzina |
| collection | DOAJ |
| description | <h4>Background</h4>Frailty has emerged as an important prognostic marker of adverse outcomes after cardiac surgery, but evidence regarding its ability to predict quality of life after cardiac surgery is currently lacking. Whether frail patients derive the same quality of life benefit after cardiac surgery as patients without frailty remains unclear.<h4>Methods</h4>This systematic review will include interventional studies (RCT and others) and observational studies evaluating the effect of preoperative frailty on quality-of-life outcomes after cardiac surgery amongst patients 65 years and older. Studies will be retrieved from major databases including the Cochrane Central Register of Controlled Trials, Embase, and Medline. The primary exposure will be frailty status, independent of the tool used. The primary outcome will be change in quality of life, independent of the tool used. Secondary outcomes will include readmission during the year following the index intervention, discharge to a long-term care facility and living in a long-term care facility at one year. Screening, inclusion, data extraction and quality assessment will be performed independently by two reviewers. Meta-analysis based on the random-effects model will be conducted to compare the outcomes between frail and non-frail patients. The evidential quality of the findings will be assessed with the GRADE profiler.<h4>Conclusion</h4>The findings of this systematic review will be important to clinicians, patients and health policy-makers regarding the use of preoperative frailty as a screening and assessment tool before cardiac surgery.<h4>Study registration</h4>OSF registries (https://osf.io/vm2p8). |
| first_indexed | 2024-12-20T18:50:55Z |
| format | Article |
| id | doaj.art-5a762f0d616a4668beda8c6c404e7316 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T18:50:55Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5a762f0d616a4668beda8c6c404e73162022-12-21T19:29:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172e026274210.1371/journal.pone.0262742Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis.Kathryn BezzinaChristophe A FehlmannMing Hao GuoSarah M VisintiniFraser D RubensGeorge A WellsRosetta MazzolaCaroline McGuintyAllen HuangLara KhouryKevin Emery Boczar<h4>Background</h4>Frailty has emerged as an important prognostic marker of adverse outcomes after cardiac surgery, but evidence regarding its ability to predict quality of life after cardiac surgery is currently lacking. Whether frail patients derive the same quality of life benefit after cardiac surgery as patients without frailty remains unclear.<h4>Methods</h4>This systematic review will include interventional studies (RCT and others) and observational studies evaluating the effect of preoperative frailty on quality-of-life outcomes after cardiac surgery amongst patients 65 years and older. Studies will be retrieved from major databases including the Cochrane Central Register of Controlled Trials, Embase, and Medline. The primary exposure will be frailty status, independent of the tool used. The primary outcome will be change in quality of life, independent of the tool used. Secondary outcomes will include readmission during the year following the index intervention, discharge to a long-term care facility and living in a long-term care facility at one year. Screening, inclusion, data extraction and quality assessment will be performed independently by two reviewers. Meta-analysis based on the random-effects model will be conducted to compare the outcomes between frail and non-frail patients. The evidential quality of the findings will be assessed with the GRADE profiler.<h4>Conclusion</h4>The findings of this systematic review will be important to clinicians, patients and health policy-makers regarding the use of preoperative frailty as a screening and assessment tool before cardiac surgery.<h4>Study registration</h4>OSF registries (https://osf.io/vm2p8).https://doi.org/10.1371/journal.pone.0262742 |
| spellingShingle | Kathryn Bezzina Christophe A Fehlmann Ming Hao Guo Sarah M Visintini Fraser D Rubens George A Wells Rosetta Mazzola Caroline McGuinty Allen Huang Lara Khoury Kevin Emery Boczar Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis. PLoS ONE |
| title | Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis. |
| title_full | Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis. |
| title_fullStr | Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis. |
| title_full_unstemmed | Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis. |
| title_short | Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis. |
| title_sort | influence of preoperative frailty on quality of life after cardiac surgery protocol for a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0262742 |
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