2D and 3D in-Vitro models for mimicking cardiac physiology
Cardiovascular diseases are the leading cause of morbidity and mortality and a huge economic burden on the healthcare system globally. Both pharmacological and device based treatment options have emerged over the years, however, it is still a ‘holy grail’ to effectively treat some cardiovascular con...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Applications in Engineering Science |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666496822000310 |
| _version_ | 1811187704679890944 |
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| author | Gerges Abdelsayed Danish Ali Andrew Malone Jemil Saidi Manoj Myneni Keshava Rajagopal Faisal H. Cheema Aamir Hameed |
| author_facet | Gerges Abdelsayed Danish Ali Andrew Malone Jemil Saidi Manoj Myneni Keshava Rajagopal Faisal H. Cheema Aamir Hameed |
| author_sort | Gerges Abdelsayed |
| collection | DOAJ |
| description | Cardiovascular diseases are the leading cause of morbidity and mortality and a huge economic burden on the healthcare system globally. Both pharmacological and device based treatment options have emerged over the years, however, it is still a ‘holy grail’ to effectively treat some cardiovascular conditions, for example, heart failure. Any treatment option whether it is drug therapy or a device therapy, has to go through a rigorous regulatory approval process. This requires robust pre-clinical research and clinical trial results. In order to proceed to the clinical trials, pre-clinical research is very important and may take methodologies which are at the interface of biology and engineering, for example, in-vitro, ex-vivo and in-vivo models. This paper focusses on the 2D and 3D in-vitro models to mimic the pathophysiology of a specific cardiovascular disease and their advantages and limitations. |
| first_indexed | 2024-04-11T14:07:57Z |
| format | Article |
| id | doaj.art-5a798a49cdbe4624a01f4c56f971fcbc |
| institution | Directory Open Access Journal |
| issn | 2666-4968 |
| language | English |
| last_indexed | 2024-04-11T14:07:57Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Applications in Engineering Science |
| spelling | doaj.art-5a798a49cdbe4624a01f4c56f971fcbc2022-12-22T04:19:49ZengElsevierApplications in Engineering Science2666-49682022-12-01121001152D and 3D in-Vitro models for mimicking cardiac physiologyGerges Abdelsayed0Danish Ali1Andrew Malone2Jemil Saidi3Manoj Myneni4Keshava Rajagopal5Faisal H. Cheema6Aamir Hameed7Tissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, Dublin, IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, Dublin, IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, Dublin, IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, Dublin, IrelandTilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX, United StatesTilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX, United StatesTilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX, United States; HCA Healthcare Research Institute, Nashville, TN, United States; Corresponding authors at: Aamir Hameed, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland - RCSI University of Medicine and Health Sciences, Dublin, Ireland, 123 St. Stephen's Green, Dublin, Ireland, Faisal H. Cheema, Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX, HCA Healthcare Research Institute, Nashville, TNTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, RCSI University of Medicine and Health Sciences, Dublin, Ireland; Trinity Centre for Biomedical Engineering (TCBE), Trinity College Dublin (TCD), Dublin, Ireland; Corresponding authors at: Aamir Hameed, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland - RCSI University of Medicine and Health Sciences, Dublin, Ireland, 123 St. Stephen's Green, Dublin, Ireland, Faisal H. Cheema, Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX, HCA Healthcare Research Institute, Nashville, TNCardiovascular diseases are the leading cause of morbidity and mortality and a huge economic burden on the healthcare system globally. Both pharmacological and device based treatment options have emerged over the years, however, it is still a ‘holy grail’ to effectively treat some cardiovascular conditions, for example, heart failure. Any treatment option whether it is drug therapy or a device therapy, has to go through a rigorous regulatory approval process. This requires robust pre-clinical research and clinical trial results. In order to proceed to the clinical trials, pre-clinical research is very important and may take methodologies which are at the interface of biology and engineering, for example, in-vitro, ex-vivo and in-vivo models. This paper focusses on the 2D and 3D in-vitro models to mimic the pathophysiology of a specific cardiovascular disease and their advantages and limitations.http://www.sciencedirect.com/science/article/pii/S2666496822000310 |
| spellingShingle | Gerges Abdelsayed Danish Ali Andrew Malone Jemil Saidi Manoj Myneni Keshava Rajagopal Faisal H. Cheema Aamir Hameed 2D and 3D in-Vitro models for mimicking cardiac physiology Applications in Engineering Science |
| title | 2D and 3D in-Vitro models for mimicking cardiac physiology |
| title_full | 2D and 3D in-Vitro models for mimicking cardiac physiology |
| title_fullStr | 2D and 3D in-Vitro models for mimicking cardiac physiology |
| title_full_unstemmed | 2D and 3D in-Vitro models for mimicking cardiac physiology |
| title_short | 2D and 3D in-Vitro models for mimicking cardiac physiology |
| title_sort | 2d and 3d in vitro models for mimicking cardiac physiology |
| url | http://www.sciencedirect.com/science/article/pii/S2666496822000310 |
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