Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan
Context: Adnexal masses of ovarian origin are of growing concern due to high fatality associated with ovarian malignancy because they are diagnosed at advanced stage due to vague symptoms and absence of recommended screening tests. Aims: The aim was to study the prevalence of histopathologic types o...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | South Asian Journal of Cancer |
| Subjects: | |
| Online Access: | http://journal.sajc.org/article.asp?issn=2278-330X;year=2019;volume=8;issue=3;spage=168;epage=172;aulast=Rai |
| _version_ | 1818656272219635712 |
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| author | Rojna Rai Pema Choden Bhutia Ugyen Tshomo |
| author_facet | Rojna Rai Pema Choden Bhutia Ugyen Tshomo |
| author_sort | Rojna Rai |
| collection | DOAJ |
| description | Context: Adnexal masses of ovarian origin are of growing concern due to high fatality associated with ovarian malignancy because they are diagnosed at advanced stage due to vague symptoms and absence of recommended screening tests. Aims: The aim was to study the prevalence of histopathologic types of adnexal masses in different age groups and to analyze the accuracy of preoperative evaluation in diagnosing ovarian malignancy. Settings and Design: This was a cross-sectional study carried out in the Department of Obstetrics and Gynecology of a tertiary care hospital in Bhutan with gynecologic-oncology services, from January to December 2017. Subjects and Methods: Women presenting with adnexal mass were evaluated and those meeting criteria were enrolled. They were evaluated preoperatively with complete history, examination, ultrasound, and tumor markers. Risk of malignancy index (RMI) was calculated for all patients. Following surgery, histopathology results were compared with preoperative evaluation. Statistical Analysis Used: Chi-square test, t-test, Cohen's Kappa, and receiver operating characteristic curve analysis were used for statistical analysis. Results: Of 165 patients evaluated, 127 fulfilling criteria were enrolled. Adnexal masses of ovarian origin were most common (n = 102, 80.3%), of which 12.7% were malignant. Epithelial ovarian malignancy was the most common malignant ovarian tumor, serous cystadenocarcinoma being the most common. Malignancy was significantly more in older, postmenopausal women with high RMI. Seven out of 11 women with high RMI were diagnosed in Stage 3 or 4. RMI score at cutoff of 200 was 54.6% sensitive and 85.7% specific. Conclusions: Adnexal mass of ovarian origin was the most common. Malignancy was significantly more in older, postmenopausal women with high RMI. RMI showed moderate correlation in diagnosing epithelial ovarian malignancies. |
| first_indexed | 2024-12-17T03:22:57Z |
| format | Article |
| id | doaj.art-5a7b358fd0954b25bc7373a18c3c1405 |
| institution | Directory Open Access Journal |
| issn | 2278-330X |
| language | English |
| last_indexed | 2024-12-17T03:22:57Z |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-5a7b358fd0954b25bc7373a18c3c14052022-12-21T22:05:28ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2019-01-018316817210.4103/sajc.sajc_303_18Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in BhutanRojna RaiPema Choden BhutiaUgyen TshomoContext: Adnexal masses of ovarian origin are of growing concern due to high fatality associated with ovarian malignancy because they are diagnosed at advanced stage due to vague symptoms and absence of recommended screening tests. Aims: The aim was to study the prevalence of histopathologic types of adnexal masses in different age groups and to analyze the accuracy of preoperative evaluation in diagnosing ovarian malignancy. Settings and Design: This was a cross-sectional study carried out in the Department of Obstetrics and Gynecology of a tertiary care hospital in Bhutan with gynecologic-oncology services, from January to December 2017. Subjects and Methods: Women presenting with adnexal mass were evaluated and those meeting criteria were enrolled. They were evaluated preoperatively with complete history, examination, ultrasound, and tumor markers. Risk of malignancy index (RMI) was calculated for all patients. Following surgery, histopathology results were compared with preoperative evaluation. Statistical Analysis Used: Chi-square test, t-test, Cohen's Kappa, and receiver operating characteristic curve analysis were used for statistical analysis. Results: Of 165 patients evaluated, 127 fulfilling criteria were enrolled. Adnexal masses of ovarian origin were most common (n = 102, 80.3%), of which 12.7% were malignant. Epithelial ovarian malignancy was the most common malignant ovarian tumor, serous cystadenocarcinoma being the most common. Malignancy was significantly more in older, postmenopausal women with high RMI. Seven out of 11 women with high RMI were diagnosed in Stage 3 or 4. RMI score at cutoff of 200 was 54.6% sensitive and 85.7% specific. Conclusions: Adnexal mass of ovarian origin was the most common. Malignancy was significantly more in older, postmenopausal women with high RMI. RMI showed moderate correlation in diagnosing epithelial ovarian malignancies.http://journal.sajc.org/article.asp?issn=2278-330X;year=2019;volume=8;issue=3;spage=168;epage=172;aulast=RaiAdnexal massovarian cancerrisk of malignancy index |
| spellingShingle | Rojna Rai Pema Choden Bhutia Ugyen Tshomo Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan South Asian Journal of Cancer Adnexal mass ovarian cancer risk of malignancy index |
| title | Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan |
| title_full | Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan |
| title_fullStr | Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan |
| title_full_unstemmed | Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan |
| title_short | Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan |
| title_sort | clinicopathological profile of adnexal masses presenting to a tertiary care hospital in bhutan |
| topic | Adnexal mass ovarian cancer risk of malignancy index |
| url | http://journal.sajc.org/article.asp?issn=2278-330X;year=2019;volume=8;issue=3;spage=168;epage=172;aulast=Rai |
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