Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integration
Background: Phototherapy with radiation of 460–490 nm wavelengths provides the most potent therapeutic effect for neonatal jaundice. However, the efficacy of phototherapy has been estimated using single-wavelength detectors with sensitivity at approximately 460 nm. Cyclobilirubin formation capacity...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957219304875 |
| _version_ | 1818062302214094848 |
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| author | Shin Kato Osuke Iwata Yasumasa Yamada Hiroki Kakita Takaharu Yamada Hideyuki Nakashima Tokio Sugiura Satoshi Suzuki Hajime Togari |
| author_facet | Shin Kato Osuke Iwata Yasumasa Yamada Hiroki Kakita Takaharu Yamada Hideyuki Nakashima Tokio Sugiura Satoshi Suzuki Hajime Togari |
| author_sort | Shin Kato |
| collection | DOAJ |
| description | Background: Phototherapy with radiation of 460–490 nm wavelengths provides the most potent therapeutic effect for neonatal jaundice. However, the efficacy of phototherapy has been estimated using single-wavelength detectors with sensitivity at approximately 460 nm. Cyclobilirubin formation capacity (CFC), which comprises the sum of the irradiance values from three wavelengths multiplied by their specific coefficients, has been proposed as an alternative marker to evaluate the efficacy of phototherapy. This study aimed to test whether two types of phototherapy devices with distinct spectral characteristics provide similar therapeutic effects on adjustment of device-to-patient distances to deliver similar CFCs. Methods: Using a three-wavelength spectroradiometer, CFCs and footprints of the light-emitting diode and fluorescent tube devices were assessed. Having determined the device-specific distances that ensured similar CFCs, 32 newborn infants, requiring phototherapy for hyperbilirubinemia, were randomized into the light-emitting diode and fluorescent tube groups. The total serum bilirubin levels before and after phototherapy were assessed. Results: The light-emitting diode and fluorescent tube devices had comparable CFCs at distances of 60 and 50 cm, respectively. Phototherapy reduced the total serum bilirubin levels from 18.1 to 14.6 mg/dL and from 19.1 to 15.1 mg/dL in the light-emitting diode and fluorescent tube groups, respectively. The two groups did not differ significantly with respect to the patients' clinical backgrounds, serum bilirubin levels, or changes before and after phototherapy. Conclusion: At similar CFCs, the two phototherapy devices reduced the total serum bilirubin levels by comparable amounts. Hence, determining CFCs may help predict phototherapy efficacy. This may ensure better safety and greater efficacy of the treatment for newborn infants. Key Words: bilirubin, cyclobilirubin, irradiance, light-emitting diode, spectroradiometer |
| first_indexed | 2024-12-10T14:02:03Z |
| format | Article |
| id | doaj.art-5a7b42331e234d0fa43f1ad4eaf68fb1 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-10T14:02:03Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-5a7b42331e234d0fa43f1ad4eaf68fb12022-12-22T01:45:47ZengElsevierPediatrics and Neonatology1875-95722020-02-01611100105Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integrationShin Kato0Osuke Iwata1Yasumasa Yamada2Hiroki Kakita3Takaharu Yamada4Hideyuki Nakashima5Tokio Sugiura6Satoshi Suzuki7Hajime Togari8Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan; Corresponding author. Fax: +81 52 842 3449.Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Neonatology, Aichi Human Service Center Central Hospital, 713-8 Jinya-cho, Kasugai 480-0304, JapanDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Pediatrics, Kainan Hospital, 396 Minamihonda, Maegasu-cho, Yatomi 498-8502, JapanDepartment of Pediatrics, Seirei-Mikatahara General Hospital, 3453 Mikatahara-cho, Kita-ku, Hamamatsu 433-8558, JapanDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan; Department of Pediatrics, Nagoya City West Medical Center, 1-1-1 Hirate-Cho, Kita-ku, Nagoya 462-8508, JapanDepartment of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan; Department of Pediatrics, Nagoya City West Medical Center, 1-1-1 Hirate-Cho, Kita-ku, Nagoya 462-8508, JapanBackground: Phototherapy with radiation of 460–490 nm wavelengths provides the most potent therapeutic effect for neonatal jaundice. However, the efficacy of phototherapy has been estimated using single-wavelength detectors with sensitivity at approximately 460 nm. Cyclobilirubin formation capacity (CFC), which comprises the sum of the irradiance values from three wavelengths multiplied by their specific coefficients, has been proposed as an alternative marker to evaluate the efficacy of phototherapy. This study aimed to test whether two types of phototherapy devices with distinct spectral characteristics provide similar therapeutic effects on adjustment of device-to-patient distances to deliver similar CFCs. Methods: Using a three-wavelength spectroradiometer, CFCs and footprints of the light-emitting diode and fluorescent tube devices were assessed. Having determined the device-specific distances that ensured similar CFCs, 32 newborn infants, requiring phototherapy for hyperbilirubinemia, were randomized into the light-emitting diode and fluorescent tube groups. The total serum bilirubin levels before and after phototherapy were assessed. Results: The light-emitting diode and fluorescent tube devices had comparable CFCs at distances of 60 and 50 cm, respectively. Phototherapy reduced the total serum bilirubin levels from 18.1 to 14.6 mg/dL and from 19.1 to 15.1 mg/dL in the light-emitting diode and fluorescent tube groups, respectively. The two groups did not differ significantly with respect to the patients' clinical backgrounds, serum bilirubin levels, or changes before and after phototherapy. Conclusion: At similar CFCs, the two phototherapy devices reduced the total serum bilirubin levels by comparable amounts. Hence, determining CFCs may help predict phototherapy efficacy. This may ensure better safety and greater efficacy of the treatment for newborn infants. Key Words: bilirubin, cyclobilirubin, irradiance, light-emitting diode, spectroradiometerhttp://www.sciencedirect.com/science/article/pii/S1875957219304875 |
| spellingShingle | Shin Kato Osuke Iwata Yasumasa Yamada Hiroki Kakita Takaharu Yamada Hideyuki Nakashima Tokio Sugiura Satoshi Suzuki Hajime Togari Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integration Pediatrics and Neonatology |
| title | Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integration |
| title_full | Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integration |
| title_fullStr | Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integration |
| title_full_unstemmed | Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integration |
| title_short | Standardization of phototherapy for neonatal hyperbilirubinemia using multiple-wavelength irradiance integration |
| title_sort | standardization of phototherapy for neonatal hyperbilirubinemia using multiple wavelength irradiance integration |
| url | http://www.sciencedirect.com/science/article/pii/S1875957219304875 |
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