Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA

Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA

Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited for developing new antibiotics, despite an overwhe...

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Manylion Llyfryddiaeth
Prif Awduron: Jujun Zhou, John R. Horton, Dan Yu, Ren Ren, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Taylor & Francis Group 2022-09-01
Cyfres:Epigenetics
Pynciau:
s-adenosyl-l-methionine analogues
dot1l inhibitors
prmt inhibitors
pseudomembranous colitis
Mynediad Ar-lein:http://dx.doi.org/10.1080/15592294.2021.1976910

Rhyngrwyd

http://dx.doi.org/10.1080/15592294.2021.1976910

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