Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed Mice
Turmeric (<i>Curcuma longa</i>) contains various compounds that potentially improve health. Bisacurone is a turmeric-derived compound but has been less studied compared to other compounds, such as curcumin. In this study, we aimed to evaluate the anti-inflammatory and lipid-lowering effe...
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9366 |
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| author | Chaoqi He Taiki Miyazawa Chizumi Abe Takahiro Ueno Mikiko Suzuki Masashi Mizukami Kazue Kurihara Masako Toda |
| author_facet | Chaoqi He Taiki Miyazawa Chizumi Abe Takahiro Ueno Mikiko Suzuki Masashi Mizukami Kazue Kurihara Masako Toda |
| author_sort | Chaoqi He |
| collection | DOAJ |
| description | Turmeric (<i>Curcuma longa</i>) contains various compounds that potentially improve health. Bisacurone is a turmeric-derived compound but has been less studied compared to other compounds, such as curcumin. In this study, we aimed to evaluate the anti-inflammatory and lipid-lowering effects of bisacurone in high-fat diet (HFD)-fed mice. Mice were fed HFD to induce lipidemia and orally administered bisacurone daily for two weeks. Bisacurone reduced liver weight, serum cholesterol and triglyceride levels, and blood viscosity in mice. Splenocytes from bisacurone-treated mice produced lower levels of the pro-inflammatory cytokines IL-6 and TNF-α upon stimulation with a toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS), and TLR1/2 ligand, Pam3CSK4, than those from untreated mice. Bisacurone also inhibited LPS-induced IL-6 and TNF-α production in the murine macrophage cell line, RAW264.7. Western blot analysis revealed that bisacurone inhibited the phosphorylation of IKKα/β and NF-κB p65 subunit, but not of the mitogen-activated protein kinases, p38 kinase and p42/44 kinases, and c-Jun N-terminal kinase in the cells. Collectively, these results suggest that bisacurone has the potential to reduce serum lipid levels and blood viscosity in mice with high-fat diet-induced lipidemia and modulate inflammation via inhibition of NF-κB-mediated pathways. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:37Z |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5a7c428496694c9dbe6c5361e9c821b72023-11-18T07:58:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411936610.3390/ijms24119366Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed MiceChaoqi He0Taiki Miyazawa1Chizumi Abe2Takahiro Ueno3Mikiko Suzuki4Masashi Mizukami5Kazue Kurihara6Masako Toda7Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, JapanFood Biotechnology Platform Promoting Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, JapanFood Biotechnology Platform Promoting Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, JapanLaboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, JapanCenter for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575, JapanNew Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, JapanNew Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, JapanLaboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, JapanTurmeric (<i>Curcuma longa</i>) contains various compounds that potentially improve health. Bisacurone is a turmeric-derived compound but has been less studied compared to other compounds, such as curcumin. In this study, we aimed to evaluate the anti-inflammatory and lipid-lowering effects of bisacurone in high-fat diet (HFD)-fed mice. Mice were fed HFD to induce lipidemia and orally administered bisacurone daily for two weeks. Bisacurone reduced liver weight, serum cholesterol and triglyceride levels, and blood viscosity in mice. Splenocytes from bisacurone-treated mice produced lower levels of the pro-inflammatory cytokines IL-6 and TNF-α upon stimulation with a toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS), and TLR1/2 ligand, Pam3CSK4, than those from untreated mice. Bisacurone also inhibited LPS-induced IL-6 and TNF-α production in the murine macrophage cell line, RAW264.7. Western blot analysis revealed that bisacurone inhibited the phosphorylation of IKKα/β and NF-κB p65 subunit, but not of the mitogen-activated protein kinases, p38 kinase and p42/44 kinases, and c-Jun N-terminal kinase in the cells. Collectively, these results suggest that bisacurone has the potential to reduce serum lipid levels and blood viscosity in mice with high-fat diet-induced lipidemia and modulate inflammation via inhibition of NF-κB-mediated pathways.https://www.mdpi.com/1422-0067/24/11/9366bisacuronehigh-fat dietcholesterolblood viscositypro-inflammatory cytokinesNF-κB pathway |
| spellingShingle | Chaoqi He Taiki Miyazawa Chizumi Abe Takahiro Ueno Mikiko Suzuki Masashi Mizukami Kazue Kurihara Masako Toda Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed Mice International Journal of Molecular Sciences bisacurone high-fat diet cholesterol blood viscosity pro-inflammatory cytokines NF-κB pathway |
| title | Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed Mice |
| title_full | Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed Mice |
| title_fullStr | Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed Mice |
| title_full_unstemmed | Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed Mice |
| title_short | Hypolipidemic and Anti-Inflammatory Effects of <i>Curcuma longa</i>-Derived Bisacurone in High-Fat Diet-Fed Mice |
| title_sort | hypolipidemic and anti inflammatory effects of i curcuma longa i derived bisacurone in high fat diet fed mice |
| topic | bisacurone high-fat diet cholesterol blood viscosity pro-inflammatory cytokines NF-κB pathway |
| url | https://www.mdpi.com/1422-0067/24/11/9366 |
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