The Nuclear Lamina as an Organizer of Chromosome Architecture
The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its disruption affects gene expression more severely. No...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/8/2/136 |
| _version_ | 1797722335041552384 |
|---|---|
| author | Yuri Y. Shevelyov Sergey V. Ulianov |
| author_facet | Yuri Y. Shevelyov Sergey V. Ulianov |
| author_sort | Yuri Y. Shevelyov |
| collection | DOAJ |
| description | The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its disruption affects gene expression more severely. Normally, the NL serves as a backbone for multiple chromatin anchoring sites, thus shaping the spatial organization of chromosomes in the interphase nucleus. However, upon cell senescence, aging, or in some types of terminally differentiated cells and lamin-associated diseases, the loss of NL-chromatin tethering causes drastic alterations in chromosome architecture. Here, we provide an overview of the recent advances in the field of NL-chromatin interactions, focusing on their impact on chromatin positioning, compaction, repression, and spatial organization. |
| first_indexed | 2024-03-12T09:47:06Z |
| format | Article |
| id | doaj.art-5a7c99e324244cc1ab7c5f377b8e9448 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T09:47:06Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5a7c99e324244cc1ab7c5f377b8e94482023-09-02T12:49:15ZengMDPI AGCells2073-44092019-02-018213610.3390/cells8020136cells8020136The Nuclear Lamina as an Organizer of Chromosome ArchitectureYuri Y. Shevelyov0Sergey V. Ulianov1Department of Molecular Genetics of Cell, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, RussiaDivision of the Regulation of Transcription and Chromatin Dynamics, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, RussiaThe nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its disruption affects gene expression more severely. Normally, the NL serves as a backbone for multiple chromatin anchoring sites, thus shaping the spatial organization of chromosomes in the interphase nucleus. However, upon cell senescence, aging, or in some types of terminally differentiated cells and lamin-associated diseases, the loss of NL-chromatin tethering causes drastic alterations in chromosome architecture. Here, we provide an overview of the recent advances in the field of NL-chromatin interactions, focusing on their impact on chromatin positioning, compaction, repression, and spatial organization.https://www.mdpi.com/2073-4409/8/2/136nuclear laminanuclear peripherynuclear envelopelaminLADTADheterochromatinHP1H3K9me2/3 |
| spellingShingle | Yuri Y. Shevelyov Sergey V. Ulianov The Nuclear Lamina as an Organizer of Chromosome Architecture Cells nuclear lamina nuclear periphery nuclear envelope lamin LAD TAD heterochromatin HP1 H3K9me2/3 |
| title | The Nuclear Lamina as an Organizer of Chromosome Architecture |
| title_full | The Nuclear Lamina as an Organizer of Chromosome Architecture |
| title_fullStr | The Nuclear Lamina as an Organizer of Chromosome Architecture |
| title_full_unstemmed | The Nuclear Lamina as an Organizer of Chromosome Architecture |
| title_short | The Nuclear Lamina as an Organizer of Chromosome Architecture |
| title_sort | nuclear lamina as an organizer of chromosome architecture |
| topic | nuclear lamina nuclear periphery nuclear envelope lamin LAD TAD heterochromatin HP1 H3K9me2/3 |
| url | https://www.mdpi.com/2073-4409/8/2/136 |
| work_keys_str_mv | AT yuriyshevelyov thenuclearlaminaasanorganizerofchromosomearchitecture AT sergeyvulianov thenuclearlaminaasanorganizerofchromosomearchitecture AT yuriyshevelyov nuclearlaminaasanorganizerofchromosomearchitecture AT sergeyvulianov nuclearlaminaasanorganizerofchromosomearchitecture |