Genetic causes of reproductive problems in the Bosnian women population
Background: The causes of infertility and recurrent spontaneous abortions are diverse and numerous – including non-genetic and genetic factors – whereby the importance of genetic factors in pathogenesis of infertility is becoming more and more common. Chromosomal abnormalities and genetic defects ca...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2018-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/20407 |
| _version_ | 1818384730246086656 |
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| author | Mirela Mackic-Djurovic Dunja Rukavina Lejla Ahmetas |
| author_facet | Mirela Mackic-Djurovic Dunja Rukavina Lejla Ahmetas |
| author_sort | Mirela Mackic-Djurovic |
| collection | DOAJ |
| description | Background: The causes of infertility and recurrent spontaneous abortions are diverse and numerous – including non-genetic and genetic factors – whereby the importance of genetic factors in pathogenesis of infertility is becoming more and more common. Chromosomal abnormalities and genetic defects can cause reproduction failures, and for this reason genetic analysis can play an important role in reproductive problems research.
Aims and Objective: This study aims to determine the type and frequency of chromosomal
aberrations in the female population sample, as well as to determine if the difference between groups with and without chromosomal aberrations was statistically significant.
Materials and Methods: One hundred women aged 15-46 were included in the study, all
having different reproductive disorder diagnoses and requiring karyotype analysis in the Sarajevo Medical Faculty Genetic Center. Cytogenetic analysis was performed on the peripheral blood, which was cultured for four days, using GTG banding forchromosomal
analysis.
Results: Out of 100 women included in the study, an abnormal karyotype was found in 16 of them (16%). The difference between the frequency of normal and abnormal karyotype in women with reproductive problems identified in this study was found to be statistically significant. The pattern of chromosomal aberrations was similar to that reported in the previous cytogenetic studies with similar inclusion criteria.
Conclusion: This fact should be taken in the consideration in order to estimate true etiology of reproductive problems and it is a valuable information in the process of genetic counseling and decision making in assisted reproductive technology. |
| first_indexed | 2024-12-14T03:26:54Z |
| format | Article |
| id | doaj.art-5a7e02c564a74017bd80c1cf82aaa5ee |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-14T03:26:54Z |
| publishDate | 2018-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-5a7e02c564a74017bd80c1cf82aaa5ee2022-12-21T23:18:51ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762018-08-01951216https://doi.org/10.3126/ajms.v9i5.20407Genetic causes of reproductive problems in the Bosnian women populationMirela Mackic-Djurovic 0Dunja Rukavina 1Lejla Ahmetas2Assistant Professor, Center for Genetic, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina http://orcid.org/0000-0001-7198-5642Professor, Veterinary Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina http://orcid.org/0000-0002-0937-6544Research Consultant, Department of Biology, University of Sarajevo, Zmaja od Bosne 33-35, 71 000 Sarajevo, Bosnia and HerzegovinaBackground: The causes of infertility and recurrent spontaneous abortions are diverse and numerous – including non-genetic and genetic factors – whereby the importance of genetic factors in pathogenesis of infertility is becoming more and more common. Chromosomal abnormalities and genetic defects can cause reproduction failures, and for this reason genetic analysis can play an important role in reproductive problems research. Aims and Objective: This study aims to determine the type and frequency of chromosomal aberrations in the female population sample, as well as to determine if the difference between groups with and without chromosomal aberrations was statistically significant. Materials and Methods: One hundred women aged 15-46 were included in the study, all having different reproductive disorder diagnoses and requiring karyotype analysis in the Sarajevo Medical Faculty Genetic Center. Cytogenetic analysis was performed on the peripheral blood, which was cultured for four days, using GTG banding forchromosomal analysis. Results: Out of 100 women included in the study, an abnormal karyotype was found in 16 of them (16%). The difference between the frequency of normal and abnormal karyotype in women with reproductive problems identified in this study was found to be statistically significant. The pattern of chromosomal aberrations was similar to that reported in the previous cytogenetic studies with similar inclusion criteria. Conclusion: This fact should be taken in the consideration in order to estimate true etiology of reproductive problems and it is a valuable information in the process of genetic counseling and decision making in assisted reproductive technology.https://www.nepjol.info/index.php/AJMS/article/view/20407genetic causesrecurrent spontaneous abortionsstructural and numerical chromosomal aberration |
| spellingShingle | Mirela Mackic-Djurovic Dunja Rukavina Lejla Ahmetas Genetic causes of reproductive problems in the Bosnian women population Asian Journal of Medical Sciences genetic causes recurrent spontaneous abortions structural and numerical chromosomal aberration |
| title | Genetic causes of reproductive problems in the Bosnian women population |
| title_full | Genetic causes of reproductive problems in the Bosnian women population |
| title_fullStr | Genetic causes of reproductive problems in the Bosnian women population |
| title_full_unstemmed | Genetic causes of reproductive problems in the Bosnian women population |
| title_short | Genetic causes of reproductive problems in the Bosnian women population |
| title_sort | genetic causes of reproductive problems in the bosnian women population |
| topic | genetic causes recurrent spontaneous abortions structural and numerical chromosomal aberration |
| url | https://www.nepjol.info/index.php/AJMS/article/view/20407 |
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