Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7]
The discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. A recent development in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell biologists. In this regard, Drosophila germ cells ar...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2015-06-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/4-157/v1 |
| _version_ | 1818262285823508480 |
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| author | Gyanesh Singh |
| author_facet | Gyanesh Singh |
| author_sort | Gyanesh Singh |
| collection | DOAJ |
| description | The discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. A recent development in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell biologists. In this regard, Drosophila germ cells are becoming a popular model of stem cell research. In several cases, genes that controlled Drosophila stem cells were later discovered to have functional homologs in mammalian stem cells. Like mammals, Drosophila germline stem cells (GSCs) are controlled by both intrinsic as well as external signals. Inside the Drosophila testes, germline and somatic stem cells form a cluster of cells (the hub). Hub cells depend on JAK-STAT signaling, and, in absence of this signal, they do not self-renew. In Drosophila, significant changes occur within the stem cell niche that contributes to a decline in stem cell number over time. In case of aging Drosophila, somatic niche cells show reduced DE-cadherin and unpaired (Upd) proteins. Unpaired proteins are known to directly decrease stem cell number within the niches, and, overexpression of upd within niche cells restored GSCs in older males also . Stem cells in the midgut of Drosophila are also very promising. Reduced Notch signaling was found to increase the number of midgut progenitor cells. On the other hand, activation of the Notch pathway decreased proliferation of these cells. Further research in this area should lead to the discovery of additional factors that regulate stem and progenitor cells in Drosophila. |
| first_indexed | 2024-12-12T19:00:42Z |
| format | Article |
| id | doaj.art-5a7e49faf37e4fd98e7b275129ab8a45 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T19:00:42Z |
| publishDate | 2015-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-5a7e49faf37e4fd98e7b275129ab8a452022-12-22T00:15:06ZengF1000 Research LtdF1000Research2046-14022015-06-01410.12688/f1000research.6611.17099Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7]Gyanesh Singh0School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, IndiaThe discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. A recent development in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell biologists. In this regard, Drosophila germ cells are becoming a popular model of stem cell research. In several cases, genes that controlled Drosophila stem cells were later discovered to have functional homologs in mammalian stem cells. Like mammals, Drosophila germline stem cells (GSCs) are controlled by both intrinsic as well as external signals. Inside the Drosophila testes, germline and somatic stem cells form a cluster of cells (the hub). Hub cells depend on JAK-STAT signaling, and, in absence of this signal, they do not self-renew. In Drosophila, significant changes occur within the stem cell niche that contributes to a decline in stem cell number over time. In case of aging Drosophila, somatic niche cells show reduced DE-cadherin and unpaired (Upd) proteins. Unpaired proteins are known to directly decrease stem cell number within the niches, and, overexpression of upd within niche cells restored GSCs in older males also . Stem cells in the midgut of Drosophila are also very promising. Reduced Notch signaling was found to increase the number of midgut progenitor cells. On the other hand, activation of the Notch pathway decreased proliferation of these cells. Further research in this area should lead to the discovery of additional factors that regulate stem and progenitor cells in Drosophila.http://f1000research.com/articles/4-157/v1Stem Cells & Regeneration |
| spellingShingle | Gyanesh Singh Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7] F1000Research Stem Cells & Regeneration |
| title | Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7] |
| title_full | Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7] |
| title_fullStr | Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7] |
| title_full_unstemmed | Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7] |
| title_short | Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7] |
| title_sort | drosophila s contribution to stem cell research v1 ref status indexed http f1000r es 5h7 |
| topic | Stem Cells & Regeneration |
| url | http://f1000research.com/articles/4-157/v1 |
| work_keys_str_mv | AT gyaneshsingh drosophilascontributiontostemcellresearchv1refstatusindexedhttpf1000res5h7 |