S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

Summary: S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA and histone methylation, tuning regulation of gene expression. Appropriate intracellular SAM levels must be maintained, because methyltransferase reaction rates can be limited by SAM availability. In respon...

Full description

Bibliographic Details
Main Authors:	Hiroki Shima, Mitsuyo Matsumoto, Yuma Ishigami, Masayuki Ebina, Akihiko Muto, Yuho Sato, Sayaka Kumagai, Kyoko Ochiai, Tsutomu Suzuki, Kazuhiko Igarashi
Format:	Article
Language:	English
Published:	Elsevier 2017-12-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S221112471731759X

Similar Items

Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function
by: Xiujuan Hu, et al.
Published: (2025-02-01)

METTL3/YTHDC1-mediated upregulation of LINC00294 promotes hepatocellular carcinoma progression
by: Rulin Zhang, et al.
Published: (2023-12-01)

METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle
by: Xinquan Zhang, et al.
Published: (2023-09-01)

A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors
by: Ari Itoh-Nakadai, et al.
Published: (2017-03-01)

S-adenosylmethionine in rat liver cirrhosis
by: Cutrin, C, et al.
Published: (1993)

S-adenosylmethionine metabolism and liver disease
by: José M. Mato, et al.
Published: (2013-03-01)

METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1
by: Zhengtao Yu, et al.
Published: (2024-10-01)

Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle
by: Liying Ruan, et al.
Published: (2019-09-01)

METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
by: Mengmeng Song, et al.
Published: (2023-12-01)

Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response
by: Miki Watanabe-Matsui, et al.
Published: (2025-01-01)

Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells
by: Hironari Nishizawa, et al.
Published: (2021-03-01)

Engineered reduction of S-adenosylmethionine alters lignin in sorghum
by: Yang Tian, et al.
Published: (2024-10-01)

WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N 6-adenosine methylation activity
by: Xuhui Yan, et al.
Published: (2023-10-01)

The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease
by: Xuejun Ge, et al.
Published: (2023-05-01)

YTHDC2-Mediated circYTHDC2 N6-Methyladenosine Modification Promotes Vascular Smooth Muscle Cells Dysfunction Through Inhibiting Ten-Eleven Translocation 2
by: Jun Yuan, et al.
Published: (2021-10-01)

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
by: Harper, J. Wade, et al.
Published: (2019)

Paramagnetic intermediates generated by radical S-adenosylmethionine (SAM) enzymes.
by: Stich, T, et al.
Published: (2014)

SPASM and Twitch Domains in S-Adenosylmethionine (SAM) Radical Enzymes
by: Goldman, Peter J., et al.
Published: (2015)

Diversity and Regulation of S-Adenosylmethionine Dependent Methyltransferases in the Anhydrobiotic Midge
by: Ruslan Deviatiiarov, et al.
Published: (2020-09-01)

Density Functional Theory Investigation of As(III) S‑Adenosylmethionine Methyltransferase
by: Seth A. Friesen, et al.
Published: (2020-08-01)

Coupling S-adenosylmethionine-dependent methylation to growth: Design and uses.
by: Hao Luo, et al.
Published: (2019-03-01)

The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3 following its METTL3-mediated m6A methylation: a novel mechanism early during radiation-induced liver injury
by: Gui-yuan Song, et al.
Published: (2025-02-01)

Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4
by: Luo, Q, et al.
Published: (2022)

Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4
by: Qiang Luo, et al.
Published: (2022-09-01)

<i>BACH1</i> Expression Is Promoted by Tank Binding Kinase 1 (<i>TBK1</i>) in Pancreatic Cancer Cells to Increase Iron and Reduce the Expression of E-Cadherin
by: Liang Liu, et al.
Published: (2022-07-01)

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma
by: Yanmeng Wang, et al.
Published: (2023-07-01)

Characterization of S-adenosylmethionine synthetases in soybean under flooding and drought stresses
by: X. Wang, et al.
Published: (2016-06-01)

S-Adenosylmethionine, a Promising Antitumor Agent in Oral and Laryngeal Cancer
by: Laura Mosca, et al.
Published: (2022-02-01)

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
by: Janice R. Sufrin, et al.
Published: (2009-08-01)

Methionine and S-Adenosylmethionine Regulate Monascus Pigments Biosynthesis in Monascus purpureus
by: Sheng Yin, et al.
Published: (2022-06-01)

Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine.
by: Wei Ding, et al.
Published: (2018-11-01)

Knockout of the DAS gene increases S-adenosylmethionine production in Komagataella phaffii
by: Taiyu Liu, et al.
Published: (2021-01-01)

YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes
by: Zhi-wei Feng, et al.
Published: (2024-10-01)

YTHDC1-mediated microRNA maturation is essential for hematopoietic stem cells maintenance
by: Hongna Zuo, et al.
Published: (2024-10-01)

Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases
by: Huaqing Yan, et al.
Published: (2022-05-01)

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
by: Ian A Roundtree, et al.
Published: (2017-10-01)

Structure-based design of ligands of the m6A-RNA reader YTHDC1
by: Yaozong Li, et al.
Published: (2022-08-01)

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline
by: Alexis S Bailey, et al.
Published: (2017-10-01)

The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases
by: Xudong Wu, et al.
Published: (2024-05-01)

Protocol for in vitro BCR-mediated plasma cell differentiation and purification of chromatin-associated proteins
by: Kyoko Ochiai, et al.
Published: (2021-09-01)