Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model

Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model

Holoprosencephaly (HPE) is a common and severe human developmental abnormality marked by malformations of the forebrain and face. Although several genetic mutations have been linked to HPE, phenotypic outcomes range dramatically, and most cases cannot be attributed to a specific cause. Gene-environm...

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Bibliographic Details
Main Authors: Galen W. Heyne, Joshua L. Everson, Lydia J. Ansen-Wilson, Cal G. Melberg, Dustin M. Fink, Kia F. Parins, Padydeh Doroodchi, Caden M. Ulschmid, Robert J. Lipinski
Format: Article
Language:English
Published: The Company of Biologists 2016-11-01
Series:Disease Models & Mechanisms
Subjects:
Holoprosencephaly
Birth defects
Gene-environment
Hedgehog signaling
Online Access:http://dmm.biologists.org/content/9/11/1307

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