Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential.
There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0233550 |
| _version_ | 1818678340265967616 |
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| author | Masahito Morimoto Toshiaki Hashimoto Yoshimi Tsuda Tadanori Nakatsu Taisuke Kitaoka Shojiro Kyotani |
| author_facet | Masahito Morimoto Toshiaki Hashimoto Yoshimi Tsuda Tadanori Nakatsu Taisuke Kitaoka Shojiro Kyotani |
| author_sort | Masahito Morimoto |
| collection | DOAJ |
| description | There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidative stress in ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). The subjects were Japanese, 77 typical development (TD) children, 98 ASD children, samples were plasma. The subjects were divided into age groups: toddlers/preschool age (2-6 years) and school age (7-15 years), to compare the relationships among the d-ROMs levels and BAP/d-ROMs ratios. Furthermore, the correlations between the Parent-interview ASD Rating Scales (PARS) scores and the measured values were analyzed. The levels of d-ROMs were significantly higher in the ASD (7-15 years) than in TD (7-15 years). The PARS scores were significantly higher in the ASD and were significantly correlated with d-ROMs levels. These results suggested that d-ROMs and BAP/d-ROMs ratios could be objective, measured indicators that could be used in clinical practice to assess stress in ASD children. |
| first_indexed | 2024-12-17T09:13:42Z |
| format | Article |
| id | doaj.art-5a81185b535c4204a50861c928d0cad6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:13:42Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5a81185b535c4204a50861c928d0cad62022-12-21T21:55:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01155e023355010.1371/journal.pone.0233550Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential.Masahito MorimotoToshiaki HashimotoYoshimi TsudaTadanori NakatsuTaisuke KitaokaShojiro KyotaniThere are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidative stress in ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). The subjects were Japanese, 77 typical development (TD) children, 98 ASD children, samples were plasma. The subjects were divided into age groups: toddlers/preschool age (2-6 years) and school age (7-15 years), to compare the relationships among the d-ROMs levels and BAP/d-ROMs ratios. Furthermore, the correlations between the Parent-interview ASD Rating Scales (PARS) scores and the measured values were analyzed. The levels of d-ROMs were significantly higher in the ASD (7-15 years) than in TD (7-15 years). The PARS scores were significantly higher in the ASD and were significantly correlated with d-ROMs levels. These results suggested that d-ROMs and BAP/d-ROMs ratios could be objective, measured indicators that could be used in clinical practice to assess stress in ASD children.https://doi.org/10.1371/journal.pone.0233550 |
| spellingShingle | Masahito Morimoto Toshiaki Hashimoto Yoshimi Tsuda Tadanori Nakatsu Taisuke Kitaoka Shojiro Kyotani Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential. PLoS ONE |
| title | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential. |
| title_full | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential. |
| title_fullStr | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential. |
| title_full_unstemmed | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential. |
| title_short | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential. |
| title_sort | assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
| url | https://doi.org/10.1371/journal.pone.0233550 |
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