A retrospective study on potential drug interactions: A single center experience
Background: In this study, it is aimed to explain the type and frequency of potential drug-drug interactions (pDDI) in patients a Medical oncology service. Methods: This study retrospective descriptive design. pDDIs were identified using the checker programme (Medscape®). Interactions were classifie...
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| Format: | Article |
| Language: | English |
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Turkiye Klinikleri
2018-08-01
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| Series: | Journal of Oncological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245233641830013X |
| _version_ | 1828022780505882624 |
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| author | Fatma Ceyda Korucu Ece Senyigit Osman Köstek Nazım Can Demircan Bulent Erdogan Sernaz Uzunoglu Irfan Cicin |
| author_facet | Fatma Ceyda Korucu Ece Senyigit Osman Köstek Nazım Can Demircan Bulent Erdogan Sernaz Uzunoglu Irfan Cicin |
| author_sort | Fatma Ceyda Korucu |
| collection | DOAJ |
| description | Background: In this study, it is aimed to explain the type and frequency of potential drug-drug interactions (pDDI) in patients a Medical oncology service. Methods: This study retrospective descriptive design. pDDIs were identified using the checker programme (Medscape®). Interactions were classified according to their clinical relevance as minor, moderate and major as appropriate. Results: The prevalence of pDDIs was 71.3% and median age was 61 years-old (interquartile range 54–68) and female to male ratio was 116/211. The median number of drugs per patient was 8 (interquartile range 5–10). A total of 1102 pDDIs of 327 hospitalized cancer patients were identified. Of those, 16.7% were major and 61.8% moderate, respectively. Concomitant use of opioids was the most common interaction in our study. Conclusions: Drug interactions were common in hospitalized cancer patients. In order to prevent potential hazardous effect of pDDI, awareness of the physicians should be increased about this issue. Keywords: Cancer patients, Oncology, Polypharmacy, Drug interaction, Chemotherapy |
| first_indexed | 2024-04-10T12:15:36Z |
| format | Article |
| id | doaj.art-5a820194e0fc47629a982aed4ba5ecb9 |
| institution | Directory Open Access Journal |
| issn | 2452-3364 |
| language | English |
| last_indexed | 2024-04-10T12:15:36Z |
| publishDate | 2018-08-01 |
| publisher | Turkiye Klinikleri |
| record_format | Article |
| series | Journal of Oncological Sciences |
| spelling | doaj.art-5a820194e0fc47629a982aed4ba5ecb92023-02-15T16:15:46ZengTurkiye KlinikleriJournal of Oncological Sciences2452-33642018-08-01428084A retrospective study on potential drug interactions: A single center experienceFatma Ceyda Korucu0Ece Senyigit1Osman Köstek2Nazım Can Demircan3Bulent Erdogan4Sernaz Uzunoglu5Irfan Cicin6Trakya University Health Center for Medical Research and Practice, Edirne, Turkey; Corresponding author.Faculty of Medicine, Trakya University, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Trakya University, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Trakya University, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Trakya University, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Trakya University, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Trakya University, TurkeyBackground: In this study, it is aimed to explain the type and frequency of potential drug-drug interactions (pDDI) in patients a Medical oncology service. Methods: This study retrospective descriptive design. pDDIs were identified using the checker programme (Medscape®). Interactions were classified according to their clinical relevance as minor, moderate and major as appropriate. Results: The prevalence of pDDIs was 71.3% and median age was 61 years-old (interquartile range 54–68) and female to male ratio was 116/211. The median number of drugs per patient was 8 (interquartile range 5–10). A total of 1102 pDDIs of 327 hospitalized cancer patients were identified. Of those, 16.7% were major and 61.8% moderate, respectively. Concomitant use of opioids was the most common interaction in our study. Conclusions: Drug interactions were common in hospitalized cancer patients. In order to prevent potential hazardous effect of pDDI, awareness of the physicians should be increased about this issue. Keywords: Cancer patients, Oncology, Polypharmacy, Drug interaction, Chemotherapyhttp://www.sciencedirect.com/science/article/pii/S245233641830013X |
| spellingShingle | Fatma Ceyda Korucu Ece Senyigit Osman Köstek Nazım Can Demircan Bulent Erdogan Sernaz Uzunoglu Irfan Cicin A retrospective study on potential drug interactions: A single center experience Journal of Oncological Sciences |
| title | A retrospective study on potential drug interactions: A single center experience |
| title_full | A retrospective study on potential drug interactions: A single center experience |
| title_fullStr | A retrospective study on potential drug interactions: A single center experience |
| title_full_unstemmed | A retrospective study on potential drug interactions: A single center experience |
| title_short | A retrospective study on potential drug interactions: A single center experience |
| title_sort | retrospective study on potential drug interactions a single center experience |
| url | http://www.sciencedirect.com/science/article/pii/S245233641830013X |
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