Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study
<b>Background: </b> Abnormalities of the nail unit are common in patients with connective tissue diseases. Clinical examination of the nail unit, coupled with biopsy of proximal nail fold offers an additional advantage in the diagnosis. <b> Purpose:</b> Our aim was to record...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2006-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2006;volume=51;issue=4;spage=265;epage=268;aulast=Nabil |
| _version_ | 1811266217788309504 |
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| author | Nabil P Rao Raghavendra Shenoi Shrutakirti Balachandran C |
| author_facet | Nabil P Rao Raghavendra Shenoi Shrutakirti Balachandran C |
| author_sort | Nabil P |
| collection | DOAJ |
| description | <b>Background: </b> Abnormalities of the nail unit are common in patients with connective tissue diseases. Clinical examination of the nail unit, coupled with biopsy of proximal nail fold offers an additional advantage in the diagnosis. <b> Purpose:</b> Our aim was to record clinical changes of the nail unit in connective tissue diseases and to study the histopathological (both H and E and periodic acid Schiff and direct immunofluorescence (DIF) findings of nail-fold biopsy. <b> Materials and Methods:</b> Thirty-eight confirmed cases connective tissue diseases attending skin OPD were enrolled in the study. After detailed clinical examination of the nail unit, a crescentric biopsy was taken from the proximal nail fold (PNF). Histopathological and DIF studies were was carried out. <b> Findings:</b> Nail changes could be demonstrated in 65% connective tissue diseases. Specific histopathological (H and E) and immunofluorescence findings were also encountered in many patients. <b> Conclusion:</b> Clinical examination of the nail unit offers additional clue in the diagnosis of connective tissue diseases. Though DIF of PNF biopsy is useful in the diagnosis, it is not an ideal site for H and E study, as the yield is very low.<b> Limitations: </b> Lack of adequate comparison group and non-utilization of capillary microscopy for the detection of nail fold capillary abnormalities. |
| first_indexed | 2024-04-12T20:38:14Z |
| format | Article |
| id | doaj.art-5a8645dbdae544d39deb8715ce9c612f |
| institution | Directory Open Access Journal |
| issn | 0019-5154 |
| language | English |
| last_indexed | 2024-04-12T20:38:14Z |
| publishDate | 2006-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-5a8645dbdae544d39deb8715ce9c612f2022-12-22T03:17:30ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51542006-01-01514265268Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence studyNabil PRao RaghavendraShenoi ShrutakirtiBalachandran C<b>Background: </b> Abnormalities of the nail unit are common in patients with connective tissue diseases. Clinical examination of the nail unit, coupled with biopsy of proximal nail fold offers an additional advantage in the diagnosis. <b> Purpose:</b> Our aim was to record clinical changes of the nail unit in connective tissue diseases and to study the histopathological (both H and E and periodic acid Schiff and direct immunofluorescence (DIF) findings of nail-fold biopsy. <b> Materials and Methods:</b> Thirty-eight confirmed cases connective tissue diseases attending skin OPD were enrolled in the study. After detailed clinical examination of the nail unit, a crescentric biopsy was taken from the proximal nail fold (PNF). Histopathological and DIF studies were was carried out. <b> Findings:</b> Nail changes could be demonstrated in 65% connective tissue diseases. Specific histopathological (H and E) and immunofluorescence findings were also encountered in many patients. <b> Conclusion:</b> Clinical examination of the nail unit offers additional clue in the diagnosis of connective tissue diseases. Though DIF of PNF biopsy is useful in the diagnosis, it is not an ideal site for H and E study, as the yield is very low.<b> Limitations: </b> Lack of adequate comparison group and non-utilization of capillary microscopy for the detection of nail fold capillary abnormalities.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2006;volume=51;issue=4;spage=265;epage=268;aulast=Nabil<i>Direct immunofluorescencenail-fold telangiectasiaperiodic acid Schiff positive cuticular depositsproximal nail fold biopsy</i> |
| spellingShingle | Nabil P Rao Raghavendra Shenoi Shrutakirti Balachandran C Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study Indian Journal of Dermatology <i>Direct immunofluorescence nail-fold telangiectasia periodic acid Schiff positive cuticular deposits proximal nail fold biopsy</i> |
| title | Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study |
| title_full | Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study |
| title_fullStr | Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study |
| title_full_unstemmed | Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study |
| title_short | Nail unit in collagen vascular diseases: A clinical, histopathological and direct immunofluorescence study |
| title_sort | nail unit in collagen vascular diseases a clinical histopathological and direct immunofluorescence study |
| topic | <i>Direct immunofluorescence nail-fold telangiectasia periodic acid Schiff positive cuticular deposits proximal nail fold biopsy</i> |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2006;volume=51;issue=4;spage=265;epage=268;aulast=Nabil |
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