Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval
Efficient retrieval of the synaptic vesicle (SV) membrane from the presynaptic plasma membrane, a process called endocytosis, is crucial for the fidelity of neurotransmission, particularly during sustained neural activity. Although multiple modes of endocytosis have been identified, it is clear that...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2017.00422/full |
| _version_ | 1811259413747466240 |
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| author | Yasunori Mori Shigeo Takamori |
| author_facet | Yasunori Mori Shigeo Takamori |
| author_sort | Yasunori Mori |
| collection | DOAJ |
| description | Efficient retrieval of the synaptic vesicle (SV) membrane from the presynaptic plasma membrane, a process called endocytosis, is crucial for the fidelity of neurotransmission, particularly during sustained neural activity. Although multiple modes of endocytosis have been identified, it is clear that the efficient retrieval of the major SV cargos into newly formed SVs during any of these modes is fundamental for synaptic transmission. It is currently believed that SVs are eventually reformed via a clathrin-dependent pathway. Various adaptor proteins recognize SV cargos and link them to clathrin, ensuring the efficient retrieval of the cargos into newly formed SVs. Here, we summarize our current knowledge of the molecular signatures within individual SV cargos that underlie efficient retrieval into SV membranes, as well as discuss possible contributions of the mechanisms under physiological conditions. |
| first_indexed | 2024-04-12T18:31:07Z |
| format | Article |
| id | doaj.art-5a866403e69c48cc839208ae2a877335 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T18:31:07Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-5a866403e69c48cc839208ae2a8773352022-12-22T03:21:05ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-01-011110.3389/fncel.2017.00422314594Molecular Signatures Underlying Synaptic Vesicle Cargo RetrievalYasunori MoriShigeo TakamoriEfficient retrieval of the synaptic vesicle (SV) membrane from the presynaptic plasma membrane, a process called endocytosis, is crucial for the fidelity of neurotransmission, particularly during sustained neural activity. Although multiple modes of endocytosis have been identified, it is clear that the efficient retrieval of the major SV cargos into newly formed SVs during any of these modes is fundamental for synaptic transmission. It is currently believed that SVs are eventually reformed via a clathrin-dependent pathway. Various adaptor proteins recognize SV cargos and link them to clathrin, ensuring the efficient retrieval of the cargos into newly formed SVs. Here, we summarize our current knowledge of the molecular signatures within individual SV cargos that underlie efficient retrieval into SV membranes, as well as discuss possible contributions of the mechanisms under physiological conditions.http://journal.frontiersin.org/article/10.3389/fncel.2017.00422/fullsynaptic vesiclesendocytosisclathrinendocytic motifpHluorin |
| spellingShingle | Yasunori Mori Shigeo Takamori Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval Frontiers in Cellular Neuroscience synaptic vesicles endocytosis clathrin endocytic motif pHluorin |
| title | Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval |
| title_full | Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval |
| title_fullStr | Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval |
| title_full_unstemmed | Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval |
| title_short | Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval |
| title_sort | molecular signatures underlying synaptic vesicle cargo retrieval |
| topic | synaptic vesicles endocytosis clathrin endocytic motif pHluorin |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2017.00422/full |
| work_keys_str_mv | AT yasunorimori molecularsignaturesunderlyingsynapticvesiclecargoretrieval AT shigeotakamori molecularsignaturesunderlyingsynapticvesiclecargoretrieval |