Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis
Growing evidence suggests that the gut microbiota is involved in the initiation and progression of ankylosing spondylitis (AS). In this study, we aimed to explore the gut microbiome alterations during adalimumab therapy and verify microbiome biomarkers predicting treatment response. By evaluating th...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.700570/full |
| _version_ | 1819139306063659008 |
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| author | Zena Chen Xuqi Zheng Xinyu Wu Jialing Wu Xiaomin Li Qiujing Wei Xi Zhang Linkai Fang Ou Jin Jieruo Gu |
| author_facet | Zena Chen Xuqi Zheng Xinyu Wu Jialing Wu Xiaomin Li Qiujing Wei Xi Zhang Linkai Fang Ou Jin Jieruo Gu |
| author_sort | Zena Chen |
| collection | DOAJ |
| description | Growing evidence suggests that the gut microbiota is involved in the initiation and progression of ankylosing spondylitis (AS). In this study, we aimed to explore the gut microbiome alterations during adalimumab therapy and verify microbiome biomarkers predicting treatment response. By evaluating the gut microbial features of 30 AS patients before and after adalimumab therapy for 6 months and 24 healthy controls, we confirmed that the microbiome was restored remarkably after 6 months of adalimumab therapy in AS patients. We then compared the baseline gut microbiome of 22 adalimumab responders with 8 non-responders, a higher abundance of Comamonas was revealed in the latter, although no statistical difference was found after adjusting for the false discovery rate. These results suggested that adalimumab therapy restored the gut microbiome in AS patients and indicated the utility of gut microbiome to be potential biomarkers for therapeutic evaluation. These findings provided an insight into the development of predictive tools and the establishment of precise medical interventions for clinical practice. |
| first_indexed | 2024-12-22T11:20:34Z |
| format | Article |
| id | doaj.art-5a8752dcfc3a49faa6c558b194fbe2e6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T11:20:34Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5a8752dcfc3a49faa6c558b194fbe2e62022-12-21T18:27:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-09-011210.3389/fimmu.2021.700570700570Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing SpondylitisZena ChenXuqi ZhengXinyu WuJialing WuXiaomin LiQiujing WeiXi ZhangLinkai FangOu JinJieruo GuGrowing evidence suggests that the gut microbiota is involved in the initiation and progression of ankylosing spondylitis (AS). In this study, we aimed to explore the gut microbiome alterations during adalimumab therapy and verify microbiome biomarkers predicting treatment response. By evaluating the gut microbial features of 30 AS patients before and after adalimumab therapy for 6 months and 24 healthy controls, we confirmed that the microbiome was restored remarkably after 6 months of adalimumab therapy in AS patients. We then compared the baseline gut microbiome of 22 adalimumab responders with 8 non-responders, a higher abundance of Comamonas was revealed in the latter, although no statistical difference was found after adjusting for the false discovery rate. These results suggested that adalimumab therapy restored the gut microbiome in AS patients and indicated the utility of gut microbiome to be potential biomarkers for therapeutic evaluation. These findings provided an insight into the development of predictive tools and the establishment of precise medical interventions for clinical practice.https://www.frontiersin.org/articles/10.3389/fimmu.2021.700570/fulladalimumabTNFgut microbiomeankylosing spondylitisbiomarker |
| spellingShingle | Zena Chen Xuqi Zheng Xinyu Wu Jialing Wu Xiaomin Li Qiujing Wei Xi Zhang Linkai Fang Ou Jin Jieruo Gu Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis Frontiers in Immunology adalimumab TNF gut microbiome ankylosing spondylitis biomarker |
| title | Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis |
| title_full | Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis |
| title_fullStr | Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis |
| title_full_unstemmed | Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis |
| title_short | Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis |
| title_sort | adalimumab therapy restores the gut microbiota in patients with ankylosing spondylitis |
| topic | adalimumab TNF gut microbiome ankylosing spondylitis biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.700570/full |
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