Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solut...
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Bibliographic Details
| Main Authors: |
Pooja Kumari,
Florian Aeschimann,
Dimos Gaidatzis,
Jeremy J. Keusch,
Pritha Ghosh,
Anca Neagu,
Katarzyna Pachulska-Wieczorek,
Janusz M. Bujnicki,
Heinz Gut,
Helge Großhans,
Rafal Ciosk |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-03920-7
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