Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications
Novel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe<sub>3</sub>O<sub>4</sub>) were fabricated by electrospinning. The morphology, structure, phase composition, and magnetic properties of composite scaffolds were st...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/3/529 |
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| author | Artyom S. Pryadko Vladimir V. Botvin Yulia R. Mukhortova Igor Pariy Dmitriy V. Wagner Pavel P. Laktionov Vera S. Chernonosova Boris P. Chelobanov Roman V. Chernozem Maria A. Surmeneva Andrei L. Kholkin Roman A. Surmenev |
| author_facet | Artyom S. Pryadko Vladimir V. Botvin Yulia R. Mukhortova Igor Pariy Dmitriy V. Wagner Pavel P. Laktionov Vera S. Chernonosova Boris P. Chelobanov Roman V. Chernozem Maria A. Surmeneva Andrei L. Kholkin Roman A. Surmenev |
| author_sort | Artyom S. Pryadko |
| collection | DOAJ |
| description | Novel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe<sub>3</sub>O<sub>4</sub>) were fabricated by electrospinning. The morphology, structure, phase composition, and magnetic properties of composite scaffolds were studied. Fabrication procedures of PHB/gelatin and PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub> scaffolds resulted in the formation of both core-shell and ribbon-shaped structure of the fibers. In case of hybrid PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub> scaffolds submicron-sized Fe<sub>3</sub>O<sub>4</sub> particles were observed in the surface layers of the fibers. The X-ray photoelectron spectroscopy results allowed the presence of gelatin on the fiber surface (N/C ratio–0.11) to be revealed. Incubation of the composite scaffolds in saline for 3 h decreased the amount of gelatin on the surface by more than ~75%. The differential scanning calorimetry results obtained for pure PHB scaffolds revealed a characteristic melting peak at 177.5 °C. The presence of gelatin in PHB/gelatin and PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub> scaffolds resulted in the decrease in melting temperature to 168–169 °C in comparison with pure PHB scaffolds due to the core-shell structure of the fibers. Hybrid scaffolds also demonstrated a decrease in crystallinity from 52.3% (PHB) to 16.9% (PHB/gelatin) and 9.2% (PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub>). All the prepared scaffolds were non-toxic and saturation magnetization of the composite scaffolds with magnetite was 3.27 ± 0.22 emu/g, which makes them prospective candidates for usage in biomedical applications. |
| first_indexed | 2024-03-09T23:16:33Z |
| format | Article |
| id | doaj.art-5a895cf1a0ce4e18be8403f9815cdf8b |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T23:16:33Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-5a895cf1a0ce4e18be8403f9815cdf8b2023-11-23T17:35:22ZengMDPI AGPolymers2073-43602022-01-0114352910.3390/polym14030529Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical ApplicationsArtyom S. Pryadko0Vladimir V. Botvin1Yulia R. Mukhortova2Igor Pariy3Dmitriy V. Wagner4Pavel P. Laktionov5Vera S. Chernonosova6Boris P. Chelobanov7Roman V. Chernozem8Maria A. Surmeneva9Andrei L. Kholkin10Roman A. Surmenev11Physical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaInternational Research and Development Center “Piezo- and Magnetoelectric Materials”, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaPhysical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaPhysical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaFaculty of Radiophysics, National Research Tomsk State University, 634050 Tomsk, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, RussiaPhysical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaPhysical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaInternational Research and Development Center “Piezo- and Magnetoelectric Materials”, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaPhysical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, RussiaNovel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe<sub>3</sub>O<sub>4</sub>) were fabricated by electrospinning. The morphology, structure, phase composition, and magnetic properties of composite scaffolds were studied. Fabrication procedures of PHB/gelatin and PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub> scaffolds resulted in the formation of both core-shell and ribbon-shaped structure of the fibers. In case of hybrid PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub> scaffolds submicron-sized Fe<sub>3</sub>O<sub>4</sub> particles were observed in the surface layers of the fibers. The X-ray photoelectron spectroscopy results allowed the presence of gelatin on the fiber surface (N/C ratio–0.11) to be revealed. Incubation of the composite scaffolds in saline for 3 h decreased the amount of gelatin on the surface by more than ~75%. The differential scanning calorimetry results obtained for pure PHB scaffolds revealed a characteristic melting peak at 177.5 °C. The presence of gelatin in PHB/gelatin and PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub> scaffolds resulted in the decrease in melting temperature to 168–169 °C in comparison with pure PHB scaffolds due to the core-shell structure of the fibers. Hybrid scaffolds also demonstrated a decrease in crystallinity from 52.3% (PHB) to 16.9% (PHB/gelatin) and 9.2% (PHB/gelatin/Fe<sub>3</sub>O<sub>4</sub>). All the prepared scaffolds were non-toxic and saturation magnetization of the composite scaffolds with magnetite was 3.27 ± 0.22 emu/g, which makes them prospective candidates for usage in biomedical applications.https://www.mdpi.com/2073-4360/14/3/529magnetoactive scaffoldpoly-3-hydroxybutyratemagnetitecompositecore-shell structure |
| spellingShingle | Artyom S. Pryadko Vladimir V. Botvin Yulia R. Mukhortova Igor Pariy Dmitriy V. Wagner Pavel P. Laktionov Vera S. Chernonosova Boris P. Chelobanov Roman V. Chernozem Maria A. Surmeneva Andrei L. Kholkin Roman A. Surmenev Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications Polymers magnetoactive scaffold poly-3-hydroxybutyrate magnetite composite core-shell structure |
| title | Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications |
| title_full | Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications |
| title_fullStr | Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications |
| title_full_unstemmed | Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications |
| title_short | Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications |
| title_sort | core shell magnetoactive phb gelatin magnetite composite electrospun scaffolds for biomedical applications |
| topic | magnetoactive scaffold poly-3-hydroxybutyrate magnetite composite core-shell structure |
| url | https://www.mdpi.com/2073-4360/14/3/529 |
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