Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study tool
Benzodiazepines (BZDs) are anxiolytic drugs that act on GABAa receptors and are used to treat anxiety disorders. However, these drugs come with the detrimental side effect of anterograde amnesia, or the inability to form new memories. In this review we discuss, behavioral paradigms, sex differences...
| Hlavní autoři: | , |
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| Médium: | Článek |
| Jazyk: | English |
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Frontiers Media S.A.
2023-09-01
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| Edice: | Frontiers in Pharmacology |
| Témata: | |
| On-line přístup: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1257030/full |
| _version_ | 1827818765432127488 |
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| author | Kameron Kaplan Kameron Kaplan Holly Christian Hunsberger Holly Christian Hunsberger |
| author_facet | Kameron Kaplan Kameron Kaplan Holly Christian Hunsberger Holly Christian Hunsberger |
| author_sort | Kameron Kaplan |
| collection | DOAJ |
| description | Benzodiazepines (BZDs) are anxiolytic drugs that act on GABAa receptors and are used to treat anxiety disorders. However, these drugs come with the detrimental side effect of anterograde amnesia, or the inability to form new memories. In this review we discuss, behavioral paradigms, sex differences and hormonal influences affecting BZD-induced amnesia, molecular manipulations, including the knockout of GABAa receptor subunits, and regional studies utilizing lesion and microinjection techniques targeted to the hippocampus and amygdala. Additionally, the relationship between BZD use and cognitive decline related to Alzheimer’s disease is addressed, as there is a lack of consensus on whether these drugs are involved in inducing or accelerating pathological cognitive deficits. This review aims to inspire new research directions, as there is a gap in knowledge in understanding the cellular and molecular mechanisms behind BZD-induced amnesia. Understanding these mechanisms will allow for the development of alternative treatments and potentially allow BZDs to be used as a novel tool to study Alzheimer’s disease. |
| first_indexed | 2024-03-12T00:58:05Z |
| format | Article |
| id | doaj.art-5a8a6ac3c73b4f1e94a74ae4a95294f4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T00:58:05Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5a8a6ac3c73b4f1e94a74ae4a95294f42023-09-14T10:21:51ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-09-011410.3389/fphar.2023.12570301257030Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study toolKameron Kaplan0Kameron Kaplan1Holly Christian Hunsberger2Holly Christian Hunsberger3Center for Neurodegenerative Diseases and Therapeutics, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United StatesDepartment of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, United StatesCenter for Neurodegenerative Diseases and Therapeutics, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United StatesDepartment of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, United StatesBenzodiazepines (BZDs) are anxiolytic drugs that act on GABAa receptors and are used to treat anxiety disorders. However, these drugs come with the detrimental side effect of anterograde amnesia, or the inability to form new memories. In this review we discuss, behavioral paradigms, sex differences and hormonal influences affecting BZD-induced amnesia, molecular manipulations, including the knockout of GABAa receptor subunits, and regional studies utilizing lesion and microinjection techniques targeted to the hippocampus and amygdala. Additionally, the relationship between BZD use and cognitive decline related to Alzheimer’s disease is addressed, as there is a lack of consensus on whether these drugs are involved in inducing or accelerating pathological cognitive deficits. This review aims to inspire new research directions, as there is a gap in knowledge in understanding the cellular and molecular mechanisms behind BZD-induced amnesia. Understanding these mechanisms will allow for the development of alternative treatments and potentially allow BZDs to be used as a novel tool to study Alzheimer’s disease.https://www.frontiersin.org/articles/10.3389/fphar.2023.1257030/fullbenzodiazepinesanterograde amnesiasex differencesAlzheimer’s diseaseGABAAfear conditioning |
| spellingShingle | Kameron Kaplan Kameron Kaplan Holly Christian Hunsberger Holly Christian Hunsberger Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study tool Frontiers in Pharmacology benzodiazepines anterograde amnesia sex differences Alzheimer’s disease GABAA fear conditioning |
| title | Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study tool |
| title_full | Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study tool |
| title_fullStr | Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study tool |
| title_full_unstemmed | Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study tool |
| title_short | Benzodiazepine-induced anterograde amnesia: detrimental side effect to novel study tool |
| title_sort | benzodiazepine induced anterograde amnesia detrimental side effect to novel study tool |
| topic | benzodiazepines anterograde amnesia sex differences Alzheimer’s disease GABAA fear conditioning |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1257030/full |
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