The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients
Background: Chronic HIV infection leads to severe perturbations of the B cell populations and hypo-responsiveness to vaccines. The associations between circulating B cell subpopulations and the antibody response to pneumococcal polysaccharide vaccine in antiretroviral-naïve and treated patients were...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971215001757 |
| _version_ | 1819170844418506752 |
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| author | Olga Tsachouridou Lemonia Skoura Pantelis Zebekakis Apostolia Margariti Adamantini Georgiou Michael Daniilidis Nikolaos Malisiovas Symeon Metallidis |
| author_facet | Olga Tsachouridou Lemonia Skoura Pantelis Zebekakis Apostolia Margariti Adamantini Georgiou Michael Daniilidis Nikolaos Malisiovas Symeon Metallidis |
| author_sort | Olga Tsachouridou |
| collection | DOAJ |
| description | Background: Chronic HIV infection leads to severe perturbations of the B cell populations and hypo-responsiveness to vaccines. The associations between circulating B cell subpopulations and the antibody response to pneumococcal polysaccharide vaccine in antiretroviral-naïve and treated patients were studied.
Methods: Sixty-six HIV-infected adults were grouped according to antiretroviral therapy (ART) and CD4+ cell count; 31 were ART-naïve and 35 were ART-treated, and they were matched for age, CD4 cell count, and duration of HIV infection. All subjects were immunized with the 23-valent polysaccharide vaccine against Streptococcus pneumoniae. Pre- and post-vaccination B cell subpopulations were assessed by flow cytometry. Serum IgG concentrations for vaccine serotypes were quantified by ELISA at baseline and at 4 and 48 weeks post-vaccination.
Results: Patients under highly active antiretroviral therapy (HAART) had significantly higher antibody levels against pneumococcal vaccine antigens, while an adequate number of patients responded to vaccination. Memory B cells were diminished over time, although treated patients maintained higher levels of all subsets studied, with the exception of activated memory and isotype-switched memory B cells.
Conclusions: Low concentrations of total B cells and exhausted memory B cells was the strongest independent predictor of poor pneumococcal vaccine responsiveness, emphasizing that B cell subset disturbances are associated with a poor vaccine response among HIV-infected patients. |
| first_indexed | 2024-12-22T19:41:51Z |
| format | Article |
| id | doaj.art-5a8d185ba06245fe9d79dddc8579de5b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-22T19:41:51Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-5a8d185ba06245fe9d79dddc8579de5b2022-12-21T18:14:50ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-09-0138C243110.1016/j.ijid.2015.07.008The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patientsOlga Tsachouridou0Lemonia Skoura1Pantelis Zebekakis2Apostolia Margariti3Adamantini Georgiou4Michael Daniilidis5Nikolaos Malisiovas6Symeon Metallidis71st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1, Stilponos Kyriakidi Str, 54636, Thessaloniki, Greece1st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1, Stilponos Kyriakidi Str, 54636, Thessaloniki, Greece1st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1, Stilponos Kyriakidi Str, 54636, Thessaloniki, GreeceNational AIDS Reference Centre of Northern Greece, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece1st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1, Stilponos Kyriakidi Str, 54636, Thessaloniki, Greece1st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1, Stilponos Kyriakidi Str, 54636, Thessaloniki, GreeceNational AIDS Reference Centre of Northern Greece, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece1st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1, Stilponos Kyriakidi Str, 54636, Thessaloniki, GreeceBackground: Chronic HIV infection leads to severe perturbations of the B cell populations and hypo-responsiveness to vaccines. The associations between circulating B cell subpopulations and the antibody response to pneumococcal polysaccharide vaccine in antiretroviral-naïve and treated patients were studied. Methods: Sixty-six HIV-infected adults were grouped according to antiretroviral therapy (ART) and CD4+ cell count; 31 were ART-naïve and 35 were ART-treated, and they were matched for age, CD4 cell count, and duration of HIV infection. All subjects were immunized with the 23-valent polysaccharide vaccine against Streptococcus pneumoniae. Pre- and post-vaccination B cell subpopulations were assessed by flow cytometry. Serum IgG concentrations for vaccine serotypes were quantified by ELISA at baseline and at 4 and 48 weeks post-vaccination. Results: Patients under highly active antiretroviral therapy (HAART) had significantly higher antibody levels against pneumococcal vaccine antigens, while an adequate number of patients responded to vaccination. Memory B cells were diminished over time, although treated patients maintained higher levels of all subsets studied, with the exception of activated memory and isotype-switched memory B cells. Conclusions: Low concentrations of total B cells and exhausted memory B cells was the strongest independent predictor of poor pneumococcal vaccine responsiveness, emphasizing that B cell subset disturbances are associated with a poor vaccine response among HIV-infected patients.http://www.sciencedirect.com/science/article/pii/S1201971215001757B cell subsetsMemory cellsHIV-1 infectionAntibody responsePhagocytosis |
| spellingShingle | Olga Tsachouridou Lemonia Skoura Pantelis Zebekakis Apostolia Margariti Adamantini Georgiou Michael Daniilidis Nikolaos Malisiovas Symeon Metallidis The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients International Journal of Infectious Diseases B cell subsets Memory cells HIV-1 infection Antibody response Phagocytosis |
| title | The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients |
| title_full | The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients |
| title_fullStr | The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients |
| title_full_unstemmed | The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients |
| title_short | The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients |
| title_sort | controversial impact of b cells subsets on immune response to pneumococcal vaccine in hiv 1 patients |
| topic | B cell subsets Memory cells HIV-1 infection Antibody response Phagocytosis |
| url | http://www.sciencedirect.com/science/article/pii/S1201971215001757 |
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