Basic and clinical associations between bone and cancer
Bone is one of the most common distant organs in which tumor cells tend to metastasize depending on complicated immune system and bone microenvironments. Clinical symptoms such as severe pain and bone fractures associated with bone metastases severely affect patients’ quality of life. According to t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-07-01
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| Series: | Immunological Medicine |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/25785826.2020.1754084 |
| _version_ | 1819051884083675136 |
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| author | Fang He Yoshinori Matsumoto |
| author_facet | Fang He Yoshinori Matsumoto |
| author_sort | Fang He |
| collection | DOAJ |
| description | Bone is one of the most common distant organs in which tumor cells tend to metastasize depending on complicated immune system and bone microenvironments. Clinical symptoms such as severe pain and bone fractures associated with bone metastases severely affect patients’ quality of life. According to the pathological types of bone destruction caused by the biological characteristics of different primary cancer cells, bone metastases are classified as osteolytic, osteoblastic and mixed types. Herein, we discuss the molecular mechanisms of bone metastasis and the therapeutic strategy with focus on bone metabolism. |
| first_indexed | 2024-12-21T12:11:02Z |
| format | Article |
| id | doaj.art-5a8f355227714bcebc12a78d7139b56d |
| institution | Directory Open Access Journal |
| issn | 2578-5826 |
| language | English |
| last_indexed | 2024-12-21T12:11:02Z |
| publishDate | 2020-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj.art-5a8f355227714bcebc12a78d7139b56d2022-12-21T19:04:35ZengTaylor & Francis GroupImmunological Medicine2578-58262020-07-0143310310610.1080/25785826.2020.17540841754084Basic and clinical associations between bone and cancerFang He0Yoshinori Matsumoto1Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesBone is one of the most common distant organs in which tumor cells tend to metastasize depending on complicated immune system and bone microenvironments. Clinical symptoms such as severe pain and bone fractures associated with bone metastases severely affect patients’ quality of life. According to the pathological types of bone destruction caused by the biological characteristics of different primary cancer cells, bone metastases are classified as osteolytic, osteoblastic and mixed types. Herein, we discuss the molecular mechanisms of bone metastasis and the therapeutic strategy with focus on bone metabolism.http://dx.doi.org/10.1080/25785826.2020.1754084bone metastasesbisphosphonatesdenosumab |
| spellingShingle | Fang He Yoshinori Matsumoto Basic and clinical associations between bone and cancer Immunological Medicine bone metastases bisphosphonates denosumab |
| title | Basic and clinical associations between bone and cancer |
| title_full | Basic and clinical associations between bone and cancer |
| title_fullStr | Basic and clinical associations between bone and cancer |
| title_full_unstemmed | Basic and clinical associations between bone and cancer |
| title_short | Basic and clinical associations between bone and cancer |
| title_sort | basic and clinical associations between bone and cancer |
| topic | bone metastases bisphosphonates denosumab |
| url | http://dx.doi.org/10.1080/25785826.2020.1754084 |
| work_keys_str_mv | AT fanghe basicandclinicalassociationsbetweenboneandcancer AT yoshinorimatsumoto basicandclinicalassociationsbetweenboneandcancer |