Molecular Mechanisms of Drug Resistance in Glioblastoma
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not amenable to effective surgical resection. The present review summarizes recent advances in our understanding of the molecular mechanisms of thera...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6385 |
| _version_ | 1797530117372641280 |
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| author | Maya A. Dymova Elena V. Kuligina Vladimir A. Richter |
| author_facet | Maya A. Dymova Elena V. Kuligina Vladimir A. Richter |
| author_sort | Maya A. Dymova |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not amenable to effective surgical resection. The present review summarizes recent advances in our understanding of the molecular mechanisms of therapeutic resistance of GBM to already known drugs, the molecular characteristics of glioblastoma cells, and the barriers in the brain that underlie drug resistance. We also discuss the progress that has been made in the development of new targeted drugs for glioblastoma, as well as advances in drug delivery across the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB). |
| first_indexed | 2024-03-10T10:24:22Z |
| format | Article |
| id | doaj.art-5a908876ae054385aa31fb6372a3232d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:24:22Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5a908876ae054385aa31fb6372a3232d2023-11-22T00:09:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212638510.3390/ijms22126385Molecular Mechanisms of Drug Resistance in GlioblastomaMaya A. Dymova0Elena V. Kuligina1Vladimir A. Richter2The Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaThe Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaThe Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaGlioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not amenable to effective surgical resection. The present review summarizes recent advances in our understanding of the molecular mechanisms of therapeutic resistance of GBM to already known drugs, the molecular characteristics of glioblastoma cells, and the barriers in the brain that underlie drug resistance. We also discuss the progress that has been made in the development of new targeted drugs for glioblastoma, as well as advances in drug delivery across the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB).https://www.mdpi.com/1422-0067/22/12/6385glioblastoma multiformedrug resistancemolecular mechanism |
| spellingShingle | Maya A. Dymova Elena V. Kuligina Vladimir A. Richter Molecular Mechanisms of Drug Resistance in Glioblastoma International Journal of Molecular Sciences glioblastoma multiforme drug resistance molecular mechanism |
| title | Molecular Mechanisms of Drug Resistance in Glioblastoma |
| title_full | Molecular Mechanisms of Drug Resistance in Glioblastoma |
| title_fullStr | Molecular Mechanisms of Drug Resistance in Glioblastoma |
| title_full_unstemmed | Molecular Mechanisms of Drug Resistance in Glioblastoma |
| title_short | Molecular Mechanisms of Drug Resistance in Glioblastoma |
| title_sort | molecular mechanisms of drug resistance in glioblastoma |
| topic | glioblastoma multiforme drug resistance molecular mechanism |
| url | https://www.mdpi.com/1422-0067/22/12/6385 |
| work_keys_str_mv | AT mayaadymova molecularmechanismsofdrugresistanceinglioblastoma AT elenavkuligina molecularmechanismsofdrugresistanceinglioblastoma AT vladimirarichter molecularmechanismsofdrugresistanceinglioblastoma |