Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration
Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis. Accumulating evidence has demonstrated that dysregulations of NCT are implicated in aging and age-related neurodegenerative di...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/4165 |
| _version_ | 1797537317028626432 |
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| author | Baojin Ding Masood Sepehrimanesh |
| author_facet | Baojin Ding Masood Sepehrimanesh |
| author_sort | Baojin Ding |
| collection | DOAJ |
| description | Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis. Accumulating evidence has demonstrated that dysregulations of NCT are implicated in aging and age-related neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and Huntington disease (HD). This is an emerging research field. The molecular mechanisms underlying impaired NCT and the pathogenesis leading to neurodegeneration are not clear. In this review, we comprehensively described the components of NCT machinery, including nuclear envelope (NE), nuclear pore complex (NPC), importins and exportins, RanGTPase and its regulators, and the regulatory mechanisms of nuclear transport of both protein and transcript cargos. Additionally, we discussed the possible molecular mechanisms of impaired NCT underlying aging and neurodegenerative diseases, such as ALS/FTD, HD, and AD. |
| first_indexed | 2024-03-10T12:14:22Z |
| format | Article |
| id | doaj.art-5a96500670a74a05b78b7fb59dd76334 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:14:22Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5a96500670a74a05b78b7fb59dd763342023-11-21T15:59:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228416510.3390/ijms22084165Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in NeurodegenerationBaojin Ding0Masood Sepehrimanesh1Department of Biology, University of Louisiana at Lafayette, 410 East Saint Mary Boulevard, Lafayette, LA 70503, USADepartment of Biology, University of Louisiana at Lafayette, 410 East Saint Mary Boulevard, Lafayette, LA 70503, USANucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis. Accumulating evidence has demonstrated that dysregulations of NCT are implicated in aging and age-related neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and Huntington disease (HD). This is an emerging research field. The molecular mechanisms underlying impaired NCT and the pathogenesis leading to neurodegeneration are not clear. In this review, we comprehensively described the components of NCT machinery, including nuclear envelope (NE), nuclear pore complex (NPC), importins and exportins, RanGTPase and its regulators, and the regulatory mechanisms of nuclear transport of both protein and transcript cargos. Additionally, we discussed the possible molecular mechanisms of impaired NCT underlying aging and neurodegenerative diseases, such as ALS/FTD, HD, and AD.https://www.mdpi.com/1422-0067/22/8/4165Alzheimer’s diseaseamyotrophic lateral sclerosisHuntington diseaseneurodegenerative diseasesnuclear pore complexnucleocytoplasmic transport |
| spellingShingle | Baojin Ding Masood Sepehrimanesh Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration International Journal of Molecular Sciences Alzheimer’s disease amyotrophic lateral sclerosis Huntington disease neurodegenerative diseases nuclear pore complex nucleocytoplasmic transport |
| title | Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration |
| title_full | Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration |
| title_fullStr | Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration |
| title_full_unstemmed | Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration |
| title_short | Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration |
| title_sort | nucleocytoplasmic transport regulatory mechanisms and the implications in neurodegeneration |
| topic | Alzheimer’s disease amyotrophic lateral sclerosis Huntington disease neurodegenerative diseases nuclear pore complex nucleocytoplasmic transport |
| url | https://www.mdpi.com/1422-0067/22/8/4165 |
| work_keys_str_mv | AT baojinding nucleocytoplasmictransportregulatorymechanismsandtheimplicationsinneurodegeneration AT masoodsepehrimanesh nucleocytoplasmictransportregulatorymechanismsandtheimplicationsinneurodegeneration |