Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults
Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D<sub>3</sub> per day versus placebo for six months on vitamin K sta...
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MDPI AG
2019-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/11/2/231 |
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| author | Adriana J. van Ballegooijen Joline W. J. Beulens Leon J. Schurgers Elisa J. de Koning Paul Lips Natasja M. van Schoor Marc G. Vervloet |
| author_facet | Adriana J. van Ballegooijen Joline W. J. Beulens Leon J. Schurgers Elisa J. de Koning Paul Lips Natasja M. van Schoor Marc G. Vervloet |
| author_sort | Adriana J. van Ballegooijen |
| collection | DOAJ |
| description | Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D<sub>3</sub> per day versus placebo for six months on vitamin K status in a randomized, double-blind, placebo-controlled trial with participants aged 60⁻80 years with depressive symptoms and ≥1 functional limitation for a secondary analysis. Stored baseline and six-month follow-up blood samples were available for 131 participants (<i>n</i> = 65 placebo vs. <i>n</i> = 66 vitamin D supplementation). We measured dephosphorylated uncarboxylated matrix gla protein (MGP) (dp-ucMGP) concentrations—a marker of vitamin K deficiency. Mean age was 68 years, and 89 participants (68%) were women. Vitamin K antagonists were used by 16 participants and multivitamin supplements by 50 participants. No differences in change between intervention and placebo were found (−38.5 ± 389 vs. 4.5 ± 127 (pmol/L), <i>p</i> = 0.562). When excluding vitamin K antagonist users and multivitamin users, dp-ucMGP at follow-up was significantly higher in the vitamin D group (<i>n</i> = 40) compared to placebo (<i>n</i> = 30), with a difference of 92.8 (5.7, 180) pmol/L, adjusting for baseline dp-ucMGP and sex. In conclusion, vitamin D supplementation for six months did not affect vitamin K status; however, among participants without vitamin K antagonist or multivitamin use, vitamin D supplementation influenced dp-ucMGP concentrations. |
| first_indexed | 2024-04-13T05:52:08Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-13T05:52:08Z |
| publishDate | 2019-01-01 |
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| series | Nutrients |
| spelling | doaj.art-5a96fca3517d4eb98d2d50d0c072ab572022-12-22T02:59:44ZengMDPI AGNutrients2072-66432019-01-0111223110.3390/nu11020231nu11020231Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older AdultsAdriana J. van Ballegooijen0Joline W. J. Beulens1Leon J. Schurgers2Elisa J. de Koning3Paul Lips4Natasja M. van Schoor5Marc G. Vervloet6Department of Nephrology, and Amsterdam Cardiovascular Science, VU University Medical Center, 1081 HV Amsterdam, The NetherlandsDepartment of Epidemiology & Biostatistics, and the Amsterdam Public Health Institute, VU University Medical Center, 1081 HV Amsterdam, The NetherlandsDepartment of Biochemistry, Maastricht University, 6211 LK Maastricht, The NetherlandsDepartment of Epidemiology & Biostatistics, and the Amsterdam Public Health Institute, VU University Medical Center, 1081 HV Amsterdam, The NetherlandsDepartment of Internal Medicine, and Amsterdam Public Health Research Institute, VU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Epidemiology & Biostatistics, and the Amsterdam Public Health Institute, VU University Medical Center, 1081 HV Amsterdam, The NetherlandsDepartment of Nephrology, and Amsterdam Cardiovascular Science, VU University Medical Center, 1081 HV Amsterdam, The NetherlandsVitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D<sub>3</sub> per day versus placebo for six months on vitamin K status in a randomized, double-blind, placebo-controlled trial with participants aged 60⁻80 years with depressive symptoms and ≥1 functional limitation for a secondary analysis. Stored baseline and six-month follow-up blood samples were available for 131 participants (<i>n</i> = 65 placebo vs. <i>n</i> = 66 vitamin D supplementation). We measured dephosphorylated uncarboxylated matrix gla protein (MGP) (dp-ucMGP) concentrations—a marker of vitamin K deficiency. Mean age was 68 years, and 89 participants (68%) were women. Vitamin K antagonists were used by 16 participants and multivitamin supplements by 50 participants. No differences in change between intervention and placebo were found (−38.5 ± 389 vs. 4.5 ± 127 (pmol/L), <i>p</i> = 0.562). When excluding vitamin K antagonist users and multivitamin users, dp-ucMGP at follow-up was significantly higher in the vitamin D group (<i>n</i> = 40) compared to placebo (<i>n</i> = 30), with a difference of 92.8 (5.7, 180) pmol/L, adjusting for baseline dp-ucMGP and sex. In conclusion, vitamin D supplementation for six months did not affect vitamin K status; however, among participants without vitamin K antagonist or multivitamin use, vitamin D supplementation influenced dp-ucMGP concentrations.https://www.mdpi.com/2072-6643/11/2/231vitamin D supplementationvitamin K statusrandomized controlled trial |
| spellingShingle | Adriana J. van Ballegooijen Joline W. J. Beulens Leon J. Schurgers Elisa J. de Koning Paul Lips Natasja M. van Schoor Marc G. Vervloet Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults Nutrients vitamin D supplementation vitamin K status randomized controlled trial |
| title | Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults |
| title_full | Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults |
| title_fullStr | Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults |
| title_full_unstemmed | Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults |
| title_short | Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults |
| title_sort | effect of 6 month vitamin d supplementation on plasma matrix gla protein in older adults |
| topic | vitamin D supplementation vitamin K status randomized controlled trial |
| url | https://www.mdpi.com/2072-6643/11/2/231 |
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