THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATURE
Introduction: Thrombotic thrombocytopenic purpura (TTP) is a syndrome that consists of the pentad of thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, fever and renal disease. Moskowitz was the first who described this syndrome in 1925, finding hyaline thrombi in many...
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| Format: | Article |
| Language: | English |
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Association of medical doctors Sanamed Novi Pazar
2020-06-01
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| Series: | Sanamed |
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| Online Access: | http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/382/211 |
| _version_ | 1797284014864728064 |
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| author | Stankovikj Svetlana |
| author_facet | Stankovikj Svetlana |
| author_sort | Stankovikj Svetlana |
| collection | DOAJ |
| description | Introduction: Thrombotic thrombocytopenic purpura (TTP) is a syndrome that consists of the pentad of thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, fever and renal disease. Moskowitz was the first who described this syndrome in 1925, finding hyaline thrombi in many organs. The micro thrombi cause tissue ischemia, platelet consumption, and microangiopathic hemolytic anemia. Brain involvement is common and leads to stroke, seizure, confusion, and headache. Renal injury occurs in a minority of patients and it is usually modest.
Case report: We present a 57-year old male who came to our hospital because of weakness, prostration and darkening of his urine, occurring several days before admission. On physical examination we found icteric coloring of his skin and conjunctiva, big hematoma on his right lower leg and he had neurological abnormalities presented as mild headache, disorientation and aphasia. Laboratory tests revealed anemia and thrombocytopenia and the examination of peripheral blood smear showed presence of schistocytes. Direct and indirect antiglobulin test (Coombs) was negative. Emergency treatment was started with plasmapheresis on daily basis, immunosuppressive treatment with high-dose methyl prednisolone and transfusions of red blood cells. The laboratory results and the clinical condition improved within two weeks.
Conclusion: TTP is a medical condition that can be fatal if emergency treatment with plasma pheresis is not initiated presently after suspected diagnosis. |
| first_indexed | 2024-03-07T17:41:56Z |
| format | Article |
| id | doaj.art-5a975fe22f5d4cb8a6e2311aaec9e1ca |
| institution | Directory Open Access Journal |
| issn | 1452-662X 2217-8171 |
| language | English |
| last_indexed | 2024-03-07T17:41:56Z |
| publishDate | 2020-06-01 |
| publisher | Association of medical doctors Sanamed Novi Pazar |
| record_format | Article |
| series | Sanamed |
| spelling | doaj.art-5a975fe22f5d4cb8a6e2311aaec9e1ca2024-03-02T15:58:12ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712020-06-01151616410.24125/sanamed.v15i1.382THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATUREStankovikj Svetlana0University Clinic of Hematology, Skopje, North MacedoniaIntroduction: Thrombotic thrombocytopenic purpura (TTP) is a syndrome that consists of the pentad of thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, fever and renal disease. Moskowitz was the first who described this syndrome in 1925, finding hyaline thrombi in many organs. The micro thrombi cause tissue ischemia, platelet consumption, and microangiopathic hemolytic anemia. Brain involvement is common and leads to stroke, seizure, confusion, and headache. Renal injury occurs in a minority of patients and it is usually modest. Case report: We present a 57-year old male who came to our hospital because of weakness, prostration and darkening of his urine, occurring several days before admission. On physical examination we found icteric coloring of his skin and conjunctiva, big hematoma on his right lower leg and he had neurological abnormalities presented as mild headache, disorientation and aphasia. Laboratory tests revealed anemia and thrombocytopenia and the examination of peripheral blood smear showed presence of schistocytes. Direct and indirect antiglobulin test (Coombs) was negative. Emergency treatment was started with plasmapheresis on daily basis, immunosuppressive treatment with high-dose methyl prednisolone and transfusions of red blood cells. The laboratory results and the clinical condition improved within two weeks. Conclusion: TTP is a medical condition that can be fatal if emergency treatment with plasma pheresis is not initiated presently after suspected diagnosis.http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/382/211thrombotic thrombocytopenic purpura (ttp)hemolytic uremic syndrome (hus)plasma exchange |
| spellingShingle | Stankovikj Svetlana THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATURE Sanamed thrombotic thrombocytopenic purpura (ttp) hemolytic uremic syndrome (hus) plasma exchange |
| title | THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATURE |
| title_full | THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATURE |
| title_fullStr | THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATURE |
| title_full_unstemmed | THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATURE |
| title_short | THROMBOTIC THROMBOCYTOPENIC PURPURA: A CASE REPORT AND REVIEW OF LITERATURE |
| title_sort | thrombotic thrombocytopenic purpura a case report and review of literature |
| topic | thrombotic thrombocytopenic purpura (ttp) hemolytic uremic syndrome (hus) plasma exchange |
| url | http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/382/211 |
| work_keys_str_mv | AT stankovikjsvetlana thromboticthrombocytopenicpurpuraacasereportandreviewofliterature |