Distinct translational control in CD4+ T cell subsets.
Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression studies have defined canonical signatures of T cell subsets. Changes in steady-state mRNA levels...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-05-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3642068?pdf=render |
| _version_ | 1828270704142843904 |
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| author | Eva Bjur Ola Larsson Ekaterina Yurchenko Lei Zheng Valentina Gandin Ivan Topisirovic Shui Li Carston R Wagner Nahum Sonenberg Ciriaco A Piccirillo |
| author_facet | Eva Bjur Ola Larsson Ekaterina Yurchenko Lei Zheng Valentina Gandin Ivan Topisirovic Shui Li Carston R Wagner Nahum Sonenberg Ciriaco A Piccirillo |
| author_sort | Eva Bjur |
| collection | DOAJ |
| description | Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression studies have defined canonical signatures of T cell subsets. Changes in steady-state mRNA levels, however, often do not reflect those of corresponding proteins due to post-transcriptional mechanisms including mRNA translation. Here, we unveil a unique translational signature, contrasting CD4(+)Foxp3(+) regulatory T (T(Foxp3+)) and CD4(+)Foxp3(-) non-regulatory T (TFoxp3-) cells, which imprints subset-specific protein expression. We further show that translation of eukaryotic translation initiation factor 4E (eIF4E) is induced during T cell activation and, in turn, regulates translation of cell cycle related mRNAs and proliferation in both T(Foxp3)- and T(Foxp3+) cells. Unexpectedly, eIF4E also affects Foxp3 expression and thereby lineage identity. Thus, mRNA-specific translational control directs both common and distinct cellular processes in CD4(+) T cell subsets. |
| first_indexed | 2024-04-13T05:45:49Z |
| format | Article |
| id | doaj.art-5a97d26813cd4b60ba2a11f81febd759 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-04-13T05:45:49Z |
| publishDate | 2013-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-5a97d26813cd4b60ba2a11f81febd7592022-12-22T02:59:57ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042013-05-0195e100349410.1371/journal.pgen.1003494Distinct translational control in CD4+ T cell subsets.Eva BjurOla LarssonEkaterina YurchenkoLei ZhengValentina GandinIvan TopisirovicShui LiCarston R WagnerNahum SonenbergCiriaco A PiccirilloRegulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression studies have defined canonical signatures of T cell subsets. Changes in steady-state mRNA levels, however, often do not reflect those of corresponding proteins due to post-transcriptional mechanisms including mRNA translation. Here, we unveil a unique translational signature, contrasting CD4(+)Foxp3(+) regulatory T (T(Foxp3+)) and CD4(+)Foxp3(-) non-regulatory T (TFoxp3-) cells, which imprints subset-specific protein expression. We further show that translation of eukaryotic translation initiation factor 4E (eIF4E) is induced during T cell activation and, in turn, regulates translation of cell cycle related mRNAs and proliferation in both T(Foxp3)- and T(Foxp3+) cells. Unexpectedly, eIF4E also affects Foxp3 expression and thereby lineage identity. Thus, mRNA-specific translational control directs both common and distinct cellular processes in CD4(+) T cell subsets.http://europepmc.org/articles/PMC3642068?pdf=render |
| spellingShingle | Eva Bjur Ola Larsson Ekaterina Yurchenko Lei Zheng Valentina Gandin Ivan Topisirovic Shui Li Carston R Wagner Nahum Sonenberg Ciriaco A Piccirillo Distinct translational control in CD4+ T cell subsets. PLoS Genetics |
| title | Distinct translational control in CD4+ T cell subsets. |
| title_full | Distinct translational control in CD4+ T cell subsets. |
| title_fullStr | Distinct translational control in CD4+ T cell subsets. |
| title_full_unstemmed | Distinct translational control in CD4+ T cell subsets. |
| title_short | Distinct translational control in CD4+ T cell subsets. |
| title_sort | distinct translational control in cd4 t cell subsets |
| url | http://europepmc.org/articles/PMC3642068?pdf=render |
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