A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale.
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping o...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-03-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19325892/?tool=EBI |
| _version_ | 1818836181341700096 |
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| author | Jason W Bohland Caizhi Wu Helen Barbas Hemant Bokil Mihail Bota Hans C Breiter Hollis T Cline John C Doyle Peter J Freed Ralph J Greenspan Suzanne N Haber Michael Hawrylycz Daniel G Herrera Claus C Hilgetag Z Josh Huang Allan Jones Edward G Jones Harvey J Karten David Kleinfeld Rolf Kötter Henry A Lester John M Lin Brett D Mensh Shawn Mikula Jaak Panksepp Joseph L Price Joseph Safdieh Clifford B Saper Nicholas D Schiff Jeremy D Schmahmann Bruce W Stillman Karel Svoboda Larry W Swanson Arthur W Toga David C Van Essen James D Watson Partha P Mitra |
| author_facet | Jason W Bohland Caizhi Wu Helen Barbas Hemant Bokil Mihail Bota Hans C Breiter Hollis T Cline John C Doyle Peter J Freed Ralph J Greenspan Suzanne N Haber Michael Hawrylycz Daniel G Herrera Claus C Hilgetag Z Josh Huang Allan Jones Edward G Jones Harvey J Karten David Kleinfeld Rolf Kötter Henry A Lester John M Lin Brett D Mensh Shawn Mikula Jaak Panksepp Joseph L Price Joseph Safdieh Clifford B Saper Nicholas D Schiff Jeremy D Schmahmann Bruce W Stillman Karel Svoboda Larry W Swanson Arthur W Toga David C Van Essen James D Watson Partha P Mitra |
| author_sort | Jason W Bohland |
| collection | DOAJ |
| description | In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget. |
| first_indexed | 2024-12-19T03:02:31Z |
| format | Article |
| id | doaj.art-5a980483294048fb98aef6917b624695 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-19T03:02:31Z |
| publishDate | 2009-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-5a980483294048fb98aef6917b6246952022-12-21T20:38:10ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582009-03-0153e100033410.1371/journal.pcbi.1000334A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale.Jason W BohlandCaizhi WuHelen BarbasHemant BokilMihail BotaHans C BreiterHollis T ClineJohn C DoylePeter J FreedRalph J GreenspanSuzanne N HaberMichael HawrylyczDaniel G HerreraClaus C HilgetagZ Josh HuangAllan JonesEdward G JonesHarvey J KartenDavid KleinfeldRolf KötterHenry A LesterJohn M LinBrett D MenshShawn MikulaJaak PankseppJoseph L PriceJoseph SafdiehClifford B SaperNicholas D SchiffJeremy D SchmahmannBruce W StillmanKarel SvobodaLarry W SwansonArthur W TogaDavid C Van EssenJames D WatsonPartha P MitraIn this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19325892/?tool=EBI |
| spellingShingle | Jason W Bohland Caizhi Wu Helen Barbas Hemant Bokil Mihail Bota Hans C Breiter Hollis T Cline John C Doyle Peter J Freed Ralph J Greenspan Suzanne N Haber Michael Hawrylycz Daniel G Herrera Claus C Hilgetag Z Josh Huang Allan Jones Edward G Jones Harvey J Karten David Kleinfeld Rolf Kötter Henry A Lester John M Lin Brett D Mensh Shawn Mikula Jaak Panksepp Joseph L Price Joseph Safdieh Clifford B Saper Nicholas D Schiff Jeremy D Schmahmann Bruce W Stillman Karel Svoboda Larry W Swanson Arthur W Toga David C Van Essen James D Watson Partha P Mitra A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Computational Biology |
| title | A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_full | A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_fullStr | A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_full_unstemmed | A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_short | A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_sort | proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19325892/?tool=EBI |
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