Recombinant Rabies Virus Overexpressing OX40-Ligand Enhances Humoral Immune Responses by Increasing T Follicular Helper Cells and Germinal Center B Cells

Recombinant Rabies Virus Overexpressing OX40-Ligand Enhances Humoral Immune Responses by Increasing T Follicular Helper Cells and Germinal Center B Cells

Rabies, caused by the rabies virus (RABV), remains a serious threat to public health in most countries. Development of a single-dose and efficacious rabies vaccine is the most important method to restrict rabies virus transmission. Costimulatory factor OX40-ligand (OX40L) plays a crucial role in the...

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Bibliographic Details
Main Authors: Yingying Li, Ling Zhao, Baokui Sui, Zhaochen Luo, Yachun Zhang, Yong Wang
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Vaccines
Subjects:
rabies vaccine
ox40-ligand
t follicular helper cells
germinal center b cells
plasma cells
Online Access:https://www.mdpi.com/2076-393X/8/1/144

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