Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population
Abstract As life expectancy increases and the population grows, the number of surgeries performed each year is likely to continue to increase. We evaluated whether surgery with general anesthesia increases risk for cognitive impairment in a Chinese elderly community population. The current data was...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-39300-5 |
| _version_ | 1797576766028513280 |
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| author | Wei Li Jianjun Jiang Song Zhang Ling Yue Shifu Xiao |
| author_facet | Wei Li Jianjun Jiang Song Zhang Ling Yue Shifu Xiao |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Abstract As life expectancy increases and the population grows, the number of surgeries performed each year is likely to continue to increase. We evaluated whether surgery with general anesthesia increases risk for cognitive impairment in a Chinese elderly community population. The current data was obtained from the China Longitudinal Aging Study (cohort 1) and Shanghai Brain Aging study (cohort 2). Cohort 1 included 1545 elderly people with normal cognitive function, who underwent a screening process that included physical examination, medical history, baseline and 1-year follow-up assessments of cognitive function by a face-to-face interview. Cohort 2 included an additional 194 elderly people with normal cognitive function, all of whom, unlike cohort 1, underwent T1-phase MR imaging scans. In cohort 1, 127 elderly people with normal cognitive function transformed into mild cognitive impairment, 27 into dementia, while 1391 still maintained normal cognitive function. By using Cox regression analysis, we found that surgery with general anesthesia was a risk factor for cognitive impairment (p = 0.013, HR = 1.506, 95% CI 1.091–2.078); In cohort 2, we found that elderly people with a history of surgery with general anesthesia had lower Montreal Cognitive Assessment (MoCA) scores and smaller right amygdala volume (p < 0.05). Through correlation analysis, we found that the volume of the right amygdala was significantly correlated (p = 0.003, r = 0.212) with MoCA. Then by using the linear regression analysis (mediation model), we found that surgery with general anesthesia directly affected the MoCA score by affecting the volume of the right amygdala (B = 1.315, p = 0.036 95% CI 0.088–2.542). We confirm surgery with general anesthesia as a risk factor for cognitive impairment, and its mechanism may be related to its effect on the volume of the right amygdala. |
| first_indexed | 2024-03-10T21:58:24Z |
| format | Article |
| id | doaj.art-5a9b91556c304f8f862e3fa5ffddcff3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:58:24Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-5a9b91556c304f8f862e3fa5ffddcff32023-11-19T13:02:15ZengNature PortfolioScientific Reports2045-23222023-08-011311810.1038/s41598-023-39300-5Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community populationWei Li0Jianjun Jiang1Song Zhang2Ling Yue3Shifu Xiao4Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineDepartment of Anorectal, KongJiang Hospital of Yangpu DistrictDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineDepartment of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineAbstract As life expectancy increases and the population grows, the number of surgeries performed each year is likely to continue to increase. We evaluated whether surgery with general anesthesia increases risk for cognitive impairment in a Chinese elderly community population. The current data was obtained from the China Longitudinal Aging Study (cohort 1) and Shanghai Brain Aging study (cohort 2). Cohort 1 included 1545 elderly people with normal cognitive function, who underwent a screening process that included physical examination, medical history, baseline and 1-year follow-up assessments of cognitive function by a face-to-face interview. Cohort 2 included an additional 194 elderly people with normal cognitive function, all of whom, unlike cohort 1, underwent T1-phase MR imaging scans. In cohort 1, 127 elderly people with normal cognitive function transformed into mild cognitive impairment, 27 into dementia, while 1391 still maintained normal cognitive function. By using Cox regression analysis, we found that surgery with general anesthesia was a risk factor for cognitive impairment (p = 0.013, HR = 1.506, 95% CI 1.091–2.078); In cohort 2, we found that elderly people with a history of surgery with general anesthesia had lower Montreal Cognitive Assessment (MoCA) scores and smaller right amygdala volume (p < 0.05). Through correlation analysis, we found that the volume of the right amygdala was significantly correlated (p = 0.003, r = 0.212) with MoCA. Then by using the linear regression analysis (mediation model), we found that surgery with general anesthesia directly affected the MoCA score by affecting the volume of the right amygdala (B = 1.315, p = 0.036 95% CI 0.088–2.542). We confirm surgery with general anesthesia as a risk factor for cognitive impairment, and its mechanism may be related to its effect on the volume of the right amygdala.https://doi.org/10.1038/s41598-023-39300-5 |
| spellingShingle | Wei Li Jianjun Jiang Song Zhang Ling Yue Shifu Xiao Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population Scientific Reports |
| title | Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population |
| title_full | Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population |
| title_fullStr | Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population |
| title_full_unstemmed | Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population |
| title_short | Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population |
| title_sort | prospective association of general anesthesia with risk of cognitive decline in a chinese elderly community population |
| url | https://doi.org/10.1038/s41598-023-39300-5 |
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