External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic Surgery
Background: Acute kidney injury (AKI) is a common complication encountered in an intensive care unit (ICU). In 2020, the AKI prediction score was developed specifically for critically ill surgical patients who underwent major non-cardiothoracic surgeries. This study aimed to externally validate the...
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MDPI AG
2021-02-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/9/2/209 |
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| author | Konlawij Trongtrakul Jayanton Patumanond Piyarat Phairatwet Chaiwut Sawawiboon Anusang Chitsomkasem Sathit Kurathong Surasee Prommoon Thananda Trakarnvanich Phichayut Phinyo |
| author_facet | Konlawij Trongtrakul Jayanton Patumanond Piyarat Phairatwet Chaiwut Sawawiboon Anusang Chitsomkasem Sathit Kurathong Surasee Prommoon Thananda Trakarnvanich Phichayut Phinyo |
| author_sort | Konlawij Trongtrakul |
| collection | DOAJ |
| description | Background: Acute kidney injury (AKI) is a common complication encountered in an intensive care unit (ICU). In 2020, the AKI prediction score was developed specifically for critically ill surgical patients who underwent major non-cardiothoracic surgeries. This study aimed to externally validate the AKI prediction score in terms of performance and clinical utility. Methods: External validation was carried out in a prospective cohort of patients admitted to the ICU of the Faculty of Medicine Vajira Hospital between September 2014 and September 2015. The endpoint was AKI within seven days following ICU admission. Discriminative ability was based on the area under the receiver operating characteristic curves (AuROC). Calibration and clinical usefulness were evaluated. Results: A total of 201 patients were included in the analysis. AKI occurred in 37 (18.4%) patients. The discriminative ability dropped from good in the derivation cohort, to acceptable in the validation cohort (0.839 (95%CI 0.825–0.852) vs. 0.745 (95%CI 0.652–0.838)). No evidence of lack-of-fit was identified (<i>p</i> = 0.754). The score had potential clinical usefulness across the range of threshold probability from 10 to 50%. Conclusions: The AKI prediction score showed an acceptable discriminative performance and calibration with potential clinical usefulness for predicting AKI risk in surgical patients who underwent major non-cardiothoracic surgery. |
| first_indexed | 2024-03-09T00:51:25Z |
| format | Article |
| id | doaj.art-5a9c3eb6db3f403fbd8a296c165b9062 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T00:51:25Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-5a9c3eb6db3f403fbd8a296c165b90622023-12-11T17:08:49ZengMDPI AGHealthcare2227-90322021-02-019220910.3390/healthcare9020209External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic SurgeryKonlawij Trongtrakul0Jayanton Patumanond1Piyarat Phairatwet2Chaiwut Sawawiboon3Anusang Chitsomkasem4Sathit Kurathong5Surasee Prommoon6Thananda Trakarnvanich7Phichayut Phinyo8Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandCenter for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandDepartment of Internal Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandDepartment of Internal Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandDepartment of Internal Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandDepartment of Internal Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandDepartment of Internal Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandCenter for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandBackground: Acute kidney injury (AKI) is a common complication encountered in an intensive care unit (ICU). In 2020, the AKI prediction score was developed specifically for critically ill surgical patients who underwent major non-cardiothoracic surgeries. This study aimed to externally validate the AKI prediction score in terms of performance and clinical utility. Methods: External validation was carried out in a prospective cohort of patients admitted to the ICU of the Faculty of Medicine Vajira Hospital between September 2014 and September 2015. The endpoint was AKI within seven days following ICU admission. Discriminative ability was based on the area under the receiver operating characteristic curves (AuROC). Calibration and clinical usefulness were evaluated. Results: A total of 201 patients were included in the analysis. AKI occurred in 37 (18.4%) patients. The discriminative ability dropped from good in the derivation cohort, to acceptable in the validation cohort (0.839 (95%CI 0.825–0.852) vs. 0.745 (95%CI 0.652–0.838)). No evidence of lack-of-fit was identified (<i>p</i> = 0.754). The score had potential clinical usefulness across the range of threshold probability from 10 to 50%. Conclusions: The AKI prediction score showed an acceptable discriminative performance and calibration with potential clinical usefulness for predicting AKI risk in surgical patients who underwent major non-cardiothoracic surgery.https://www.mdpi.com/2227-9032/9/2/209acute kidney injurypredictioncritical caresurgeryvalidation study |
| spellingShingle | Konlawij Trongtrakul Jayanton Patumanond Piyarat Phairatwet Chaiwut Sawawiboon Anusang Chitsomkasem Sathit Kurathong Surasee Prommoon Thananda Trakarnvanich Phichayut Phinyo External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic Surgery Healthcare acute kidney injury prediction critical care surgery validation study |
| title | External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic Surgery |
| title_full | External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic Surgery |
| title_fullStr | External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic Surgery |
| title_full_unstemmed | External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic Surgery |
| title_short | External Validation of the Acute Kidney Injury Risk Prediction Score for Critically Ill Surgical Patients Who Underwent Major Non-Cardiothoracic Surgery |
| title_sort | external validation of the acute kidney injury risk prediction score for critically ill surgical patients who underwent major non cardiothoracic surgery |
| topic | acute kidney injury prediction critical care surgery validation study |
| url | https://www.mdpi.com/2227-9032/9/2/209 |
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