Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis
About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrume...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/4/222 |
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| author | Alice Castaldo Paola Iacotucci Vincenzo Carnovale Roberta Cimino Renato Liguori Marika Comegna Valeria Raia Gaetano Corso Giuseppe Castaldo Monica Gelzo |
| author_facet | Alice Castaldo Paola Iacotucci Vincenzo Carnovale Roberta Cimino Renato Liguori Marika Comegna Valeria Raia Gaetano Corso Giuseppe Castaldo Monica Gelzo |
| author_sort | Alice Castaldo |
| collection | DOAJ |
| description | About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrumental procedures, while monitoring of lung inflammation requires invasive collection of bronchoalveolar lavage fluid. The aim of this study was to investigate the associations between salivary cytokines levels and CF-related airway diseases. Salivary biochemical parameters and cytokines, i.e., interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-α), were analyzed in resting saliva from healthy subjects and patients with CF. Patients with CF showed significantly higher levels of salivary chloride, IL-6, IL-8, and TNF-α and lower calcium levels than healthy subjects. Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-α was significantly lower in patients with NP. A decreasing trend of TNF-α in patients with severe lung disease was also observed. On the other hand, we did not find significant correlation between cytokine levels and <i>Pseudomonas aeruginosa</i> or <i>Stenotrophomonas maltophilia</i> colonization. These preliminary results suggest that salivary IL-6 and IL-8 levels increase during the acute phase of sinonasal disease (i.e., NTH), while the end stages of pulmonary disease and sinonasal disease (i.e., NP) show decreased TNF-α levels. |
| first_indexed | 2024-03-10T20:27:05Z |
| format | Article |
| id | doaj.art-5aa2a3a728a94e319702e51eb11f901b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:27:05Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5aa2a3a728a94e319702e51eb11f901b2023-11-19T21:41:54ZengMDPI AGDiagnostics2075-44182020-04-0110422210.3390/diagnostics10040222Salivary Cytokines and Airways Disease Severity in Patients with Cystic FibrosisAlice Castaldo0Paola Iacotucci1Vincenzo Carnovale2Roberta Cimino3Renato Liguori4Marika Comegna5Valeria Raia6Gaetano Corso7Giuseppe Castaldo8Monica Gelzo9Dipartimento di Scienze Mediche Traslazionali, University of Naples Federico II, 80131 Naples, ItalyDipartimento di Scienze Mediche Traslazionali, University of Naples Federico II, 80131 Naples, ItalyDipartimento di Scienze Mediche Traslazionali, University of Naples Federico II, 80131 Naples, ItalyDipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, University of Naples Federico II, 80131 Naples, ItalyDipartimento di Scienze e Tecnologie, University of Naples Parthenope, 80133 Naples, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, 80138 Naples, ItalyDipartimento di Scienze Mediche Traslazionali, University of Naples Federico II, 80131 Naples, ItalyDipartimento di Medicina Clinica e Sperimentale, University of Foggia, 71122 Foggia, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, 80138 Naples, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, 80138 Naples, ItalyAbout 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrumental procedures, while monitoring of lung inflammation requires invasive collection of bronchoalveolar lavage fluid. The aim of this study was to investigate the associations between salivary cytokines levels and CF-related airway diseases. Salivary biochemical parameters and cytokines, i.e., interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-α), were analyzed in resting saliva from healthy subjects and patients with CF. Patients with CF showed significantly higher levels of salivary chloride, IL-6, IL-8, and TNF-α and lower calcium levels than healthy subjects. Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-α was significantly lower in patients with NP. A decreasing trend of TNF-α in patients with severe lung disease was also observed. On the other hand, we did not find significant correlation between cytokine levels and <i>Pseudomonas aeruginosa</i> or <i>Stenotrophomonas maltophilia</i> colonization. These preliminary results suggest that salivary IL-6 and IL-8 levels increase during the acute phase of sinonasal disease (i.e., NTH), while the end stages of pulmonary disease and sinonasal disease (i.e., NP) show decreased TNF-α levels.https://www.mdpi.com/2075-4418/10/4/222cystic fibrosisinferior turbinates hypertrophynasal polyposissalivary cytokines |
| spellingShingle | Alice Castaldo Paola Iacotucci Vincenzo Carnovale Roberta Cimino Renato Liguori Marika Comegna Valeria Raia Gaetano Corso Giuseppe Castaldo Monica Gelzo Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis Diagnostics cystic fibrosis inferior turbinates hypertrophy nasal polyposis salivary cytokines |
| title | Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis |
| title_full | Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis |
| title_fullStr | Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis |
| title_full_unstemmed | Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis |
| title_short | Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis |
| title_sort | salivary cytokines and airways disease severity in patients with cystic fibrosis |
| topic | cystic fibrosis inferior turbinates hypertrophy nasal polyposis salivary cytokines |
| url | https://www.mdpi.com/2075-4418/10/4/222 |
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