Genetic basis of depressive disorders
Depression is a common mental disorder being one of the main causes of disability and mortality worldwide. Despite an intensive research during the past decades, the etiology of depressive disorders (DDs) remains incompletely understood; however, genetic factors are significantly involved in the lia...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2019-07-01
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| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/2140 |
| _version_ | 1797214005228470272 |
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| author | Yu. D. Davydova R. F. Enikeeva A. V. Kazantseva R. N. Mustafin A. R. Romanova S. B. Malykh E. K. Khusnutdinov |
| author_facet | Yu. D. Davydova R. F. Enikeeva A. V. Kazantseva R. N. Mustafin A. R. Romanova S. B. Malykh E. K. Khusnutdinov |
| author_sort | Yu. D. Davydova |
| collection | DOAJ |
| description | Depression is a common mental disorder being one of the main causes of disability and mortality worldwide. Despite an intensive research during the past decades, the etiology of depressive disorders (DDs) remains incompletely understood; however, genetic factors are significantly involved in the liability to depression. The present review is focused on the studies based on a candidate gene approach, genome-wide association studies (GWAS) and whole exome sequencing (WES), which previously demonstrated associations between gene polymorphisms and DDs. According to the first approach, DD development is affected by serotonergic (TPH1, TPH2, HTR1A, HTR2A, and SLC6A4), dopaminergic (DRD4, SLC6A3) and noradrenergic (SLC6A2) system genes, and genes of enzymatic degradation (MAOA, COMT). In addition, there is evidence of the involvement of HPA-axis genes (OXTR, AVPR1A, and AVPR1B), sex hormone receptors genes (ESR1, ESR2, and AR), neurotrophin (BDNF) and methylenetetrahydrofolate reductase (MTHFR) genes, neuronal apoptosis (CASP3, BCL-XL, BAX, NPY, APP, and GRIN1) and inflammatory system (TNF, CRP, IL6, IL1B, PSMB4, PSMD9, and STAT3) genes in DD development. The results of the second approach (GWAS and WES) revealed that the PCLO, SIRT1, GNL3, GLT8D1, ITIH3, MTNR1A, BMP5, FHIT, KSR2, PCDH9, and AUTS2 genes predominantly responsible for neurogenesis and cell adhesion are involved in liability to depression. Therefore, the findings discussed suggest that genetic liability to DD is a complex process, which assumes simultaneous functioning of multiple genes including those reported previously, and requires future research in this field. |
| first_indexed | 2024-03-07T16:05:59Z |
| format | Article |
| id | doaj.art-5aa428d3fa9f4d978d1cfc208f549441 |
| institution | Directory Open Access Journal |
| issn | 2500-3259 |
| language | English |
| last_indexed | 2024-04-24T11:07:17Z |
| publishDate | 2019-07-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj.art-5aa428d3fa9f4d978d1cfc208f5494412024-04-11T15:31:01ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592019-07-0123446547210.18699/VJ19.515930Genetic basis of depressive disordersYu. D. Davydova0R. F. Enikeeva1A. V. Kazantseva2R. N. Mustafin3A. R. Romanova4S. B. Malykh5E. K. Khusnutdinov6Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RASBashkir State University; Bashkir State Medical University of the Ministry of Health of the Russian FederationSterlitamak Branch of the Bashkir State UniversityPsychological Institute of Russian Academy of EducationInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre, RAS; Bashkir State UniversityDepression is a common mental disorder being one of the main causes of disability and mortality worldwide. Despite an intensive research during the past decades, the etiology of depressive disorders (DDs) remains incompletely understood; however, genetic factors are significantly involved in the liability to depression. The present review is focused on the studies based on a candidate gene approach, genome-wide association studies (GWAS) and whole exome sequencing (WES), which previously demonstrated associations between gene polymorphisms and DDs. According to the first approach, DD development is affected by serotonergic (TPH1, TPH2, HTR1A, HTR2A, and SLC6A4), dopaminergic (DRD4, SLC6A3) and noradrenergic (SLC6A2) system genes, and genes of enzymatic degradation (MAOA, COMT). In addition, there is evidence of the involvement of HPA-axis genes (OXTR, AVPR1A, and AVPR1B), sex hormone receptors genes (ESR1, ESR2, and AR), neurotrophin (BDNF) and methylenetetrahydrofolate reductase (MTHFR) genes, neuronal apoptosis (CASP3, BCL-XL, BAX, NPY, APP, and GRIN1) and inflammatory system (TNF, CRP, IL6, IL1B, PSMB4, PSMD9, and STAT3) genes in DD development. The results of the second approach (GWAS and WES) revealed that the PCLO, SIRT1, GNL3, GLT8D1, ITIH3, MTNR1A, BMP5, FHIT, KSR2, PCDH9, and AUTS2 genes predominantly responsible for neurogenesis and cell adhesion are involved in liability to depression. Therefore, the findings discussed suggest that genetic liability to DD is a complex process, which assumes simultaneous functioning of multiple genes including those reported previously, and requires future research in this field.https://vavilov.elpub.ru/jour/article/view/2140depressive disorderserotoninhypothalamic-pituitary adrenal axisneurotrophinapoptosiscytokinesgwaswhole-exome sequencing. |
| spellingShingle | Yu. D. Davydova R. F. Enikeeva A. V. Kazantseva R. N. Mustafin A. R. Romanova S. B. Malykh E. K. Khusnutdinov Genetic basis of depressive disorders Вавиловский журнал генетики и селекции depressive disorder serotonin hypothalamic-pituitary adrenal axis neurotrophin apoptosis cytokines gwas whole-exome sequencing. |
| title | Genetic basis of depressive disorders |
| title_full | Genetic basis of depressive disorders |
| title_fullStr | Genetic basis of depressive disorders |
| title_full_unstemmed | Genetic basis of depressive disorders |
| title_short | Genetic basis of depressive disorders |
| title_sort | genetic basis of depressive disorders |
| topic | depressive disorder serotonin hypothalamic-pituitary adrenal axis neurotrophin apoptosis cytokines gwas whole-exome sequencing. |
| url | https://vavilov.elpub.ru/jour/article/view/2140 |
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